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Inhibition of the phosphoinositide 3-kinase pathway decreases innate resistance to lipopolysaccharide toxicity in TLR4 deficient mice

BACKGROUND: Upon lipopolysaccharide (LPS) stimulation, activation of both the Toll-like receptor 4 (TLR4) and phosphoinositide 3-kinase (PI3K) pathways serves to balance proinflammatory and anti-inflammatory responses. Although the antagonist to TLR4 represents an emerging promising target for the t...

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Detalles Bibliográficos
Autores principales:	Yang, Johnson Chia-Shen, Wu, Shao-Chun, Rau, Cheng-Shyuan, Lu, Tsu-Hsiang, Wu, Yi-Chan, Chen, Yi-Chun, Lin, Ming-Wei, Tzeng, Siou-Ling, Wu, Chia-Jung, Hsieh, Ching-Hua
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	BioMed Central 2014
Materias:	Research
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3995796/ https://www.ncbi.nlm.nih.gov/pubmed/24618279 http://dx.doi.org/10.1186/1423-0127-21-20

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