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Response to antiretroviral therapy (ART): comparing women with previous use of zidovudine monotherapy (ZDVm) in pregnancy with ART naïve women
BACKGROUND: Short-term zidovudine monotherapy (ZDVm) remains an option for some pregnant HIV-positive women not requiring treatment for their own health but may affect treatment responses once antiretroviral therapy (ART) is subsequently started. METHODS: Data were obtained by linking two UK studies...
Autores principales: | , , , , , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
BioMed Central
2014
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3995971/ https://www.ncbi.nlm.nih.gov/pubmed/24593018 http://dx.doi.org/10.1186/1471-2334-14-127 |
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author | Huntington, Susie Thorne, Claire Anderson, Jane Newell, Marie-Louise Taylor, Graham P Pillay, Deenan Hill, Teresa Tookey, Pat Sabin, Caroline |
author_facet | Huntington, Susie Thorne, Claire Anderson, Jane Newell, Marie-Louise Taylor, Graham P Pillay, Deenan Hill, Teresa Tookey, Pat Sabin, Caroline |
author_sort | Huntington, Susie |
collection | PubMed |
description | BACKGROUND: Short-term zidovudine monotherapy (ZDVm) remains an option for some pregnant HIV-positive women not requiring treatment for their own health but may affect treatment responses once antiretroviral therapy (ART) is subsequently started. METHODS: Data were obtained by linking two UK studies: the UK Collaborative HIV Cohort (UK CHIC) study and the National Study of HIV in Pregnancy and Childhood (NSHPC). Treatment responses were assessed for 2028 women initiating ART at least one year after HIV-diagnosis. Outcomes were compared using logistic regression, proportional hazards regression or linear regression. RESULTS: In adjusted analyses, ART-naïve (n = 1937) and ZDVm-experienced (n = 91) women had similar increases in CD4 count and a similar proportion achieving virological suppression; both groups had a low risk of AIDS. CONCLUSIONS: In this setting, antenatal ZDVm exposure did not adversely impact on outcomes once ART was initiated for the woman’s health. |
format | Online Article Text |
id | pubmed-3995971 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2014 |
publisher | BioMed Central |
record_format | MEDLINE/PubMed |
spelling | pubmed-39959712014-04-23 Response to antiretroviral therapy (ART): comparing women with previous use of zidovudine monotherapy (ZDVm) in pregnancy with ART naïve women Huntington, Susie Thorne, Claire Anderson, Jane Newell, Marie-Louise Taylor, Graham P Pillay, Deenan Hill, Teresa Tookey, Pat Sabin, Caroline BMC Infect Dis Research Article BACKGROUND: Short-term zidovudine monotherapy (ZDVm) remains an option for some pregnant HIV-positive women not requiring treatment for their own health but may affect treatment responses once antiretroviral therapy (ART) is subsequently started. METHODS: Data were obtained by linking two UK studies: the UK Collaborative HIV Cohort (UK CHIC) study and the National Study of HIV in Pregnancy and Childhood (NSHPC). Treatment responses were assessed for 2028 women initiating ART at least one year after HIV-diagnosis. Outcomes were compared using logistic regression, proportional hazards regression or linear regression. RESULTS: In adjusted analyses, ART-naïve (n = 1937) and ZDVm-experienced (n = 91) women had similar increases in CD4 count and a similar proportion achieving virological suppression; both groups had a low risk of AIDS. CONCLUSIONS: In this setting, antenatal ZDVm exposure did not adversely impact on outcomes once ART was initiated for the woman’s health. BioMed Central 2014-03-04 /pmc/articles/PMC3995971/ /pubmed/24593018 http://dx.doi.org/10.1186/1471-2334-14-127 Text en Copyright © 2014 Huntington et al.; licensee BioMed Central Ltd. http://creativecommons.org/licenses/by/2.0 This is an Open Access article distributed under the terms of the Creative Commons Attribution License (http://creativecommons.org/licenses/by/2.0), which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly credited. The Creative Commons Public Domain Dedication waiver (http://creativecommons.org/publicdomain/zero/1.0/) applies to the data made available in this article, unless otherwise stated. |
spellingShingle | Research Article Huntington, Susie Thorne, Claire Anderson, Jane Newell, Marie-Louise Taylor, Graham P Pillay, Deenan Hill, Teresa Tookey, Pat Sabin, Caroline Response to antiretroviral therapy (ART): comparing women with previous use of zidovudine monotherapy (ZDVm) in pregnancy with ART naïve women |
title | Response to antiretroviral therapy (ART): comparing women with previous use of zidovudine monotherapy (ZDVm) in pregnancy with ART naïve women |
title_full | Response to antiretroviral therapy (ART): comparing women with previous use of zidovudine monotherapy (ZDVm) in pregnancy with ART naïve women |
title_fullStr | Response to antiretroviral therapy (ART): comparing women with previous use of zidovudine monotherapy (ZDVm) in pregnancy with ART naïve women |
title_full_unstemmed | Response to antiretroviral therapy (ART): comparing women with previous use of zidovudine monotherapy (ZDVm) in pregnancy with ART naïve women |
title_short | Response to antiretroviral therapy (ART): comparing women with previous use of zidovudine monotherapy (ZDVm) in pregnancy with ART naïve women |
title_sort | response to antiretroviral therapy (art): comparing women with previous use of zidovudine monotherapy (zdvm) in pregnancy with art naïve women |
topic | Research Article |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3995971/ https://www.ncbi.nlm.nih.gov/pubmed/24593018 http://dx.doi.org/10.1186/1471-2334-14-127 |
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