Concomitant progressive supranuclear palsy and chronic traumatic encephalopathy in a boxer

We report the case of a 75-year-old ex-professional boxer who developed diplopia and eye movement abnormalities in his 60’s followed by memory impairment, low mood and recurrent falls. Examination shortly before death revealed hypomimia, dysarthria, vertical supranuclear gaze palsy and impaired post...

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Autores principales: Ling, Helen, Kara, Eleanna, Revesz, Tamas, Lees, Andrew J, Plant, Gordon T, Martino, Davide, Houlden, Henry, Hardy, John, Holton, Janice L
Formato: Online Artículo Texto
Lenguaje:English
Publicado: BioMed Central 2014
Materias:
Case Report
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3996066/
https://www.ncbi.nlm.nih.gov/pubmed/24559032
http://dx.doi.org/10.1186/2051-5960-2-24
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author Ling, Helen
Kara, Eleanna
Revesz, Tamas
Lees, Andrew J
Plant, Gordon T
Martino, Davide
Houlden, Henry
Hardy, John
Holton, Janice L
author_facet Ling, Helen
Kara, Eleanna
Revesz, Tamas
Lees, Andrew J
Plant, Gordon T
Martino, Davide
Houlden, Henry
Hardy, John
Holton, Janice L
author_sort Ling, Helen
collection PubMed
description We report the case of a 75-year-old ex-professional boxer who developed diplopia and eye movement abnormalities in his 60’s followed by memory impairment, low mood and recurrent falls. Examination shortly before death revealed hypomimia, dysarthria, vertical supranuclear gaze palsy and impaired postural reflexes. Pathological examination demonstrated 4-repeat tau neuronal and glial lesions, including tufted astrocytes, consistent with a diagnosis of progressive supranuclear palsy. In addition, neurofibrillary tangles composed of mixed 3-repeat and 4-repeat tau and astrocytic tangles in a distribution highly suggestive of chronic traumatic encephalopathy were observed together with limbic TDP-43 pathology. Possible mechanisms for the co-occurrence of these two tau pathologies are discussed.
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spelling pubmed-39960662014-04-24 Concomitant progressive supranuclear palsy and chronic traumatic encephalopathy in a boxer Ling, Helen Kara, Eleanna Revesz, Tamas Lees, Andrew J Plant, Gordon T Martino, Davide Houlden, Henry Hardy, John Holton, Janice L Acta Neuropathol Commun Case Report We report the case of a 75-year-old ex-professional boxer who developed diplopia and eye movement abnormalities in his 60’s followed by memory impairment, low mood and recurrent falls. Examination shortly before death revealed hypomimia, dysarthria, vertical supranuclear gaze palsy and impaired postural reflexes. Pathological examination demonstrated 4-repeat tau neuronal and glial lesions, including tufted astrocytes, consistent with a diagnosis of progressive supranuclear palsy. In addition, neurofibrillary tangles composed of mixed 3-repeat and 4-repeat tau and astrocytic tangles in a distribution highly suggestive of chronic traumatic encephalopathy were observed together with limbic TDP-43 pathology. Possible mechanisms for the co-occurrence of these two tau pathologies are discussed. BioMed Central 2014-02-21 /pmc/articles/PMC3996066/ /pubmed/24559032 http://dx.doi.org/10.1186/2051-5960-2-24 Text en Copyright © 2014 Ling et al.; licensee BioMed Central Ltd. http://creativecommons.org/licenses/by/2.0 This is an Open Access article distributed under the terms of the Creative Commons Attribution License ( http://creativecommons.org/licenses/by/2.0), which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly credited. The Creative Commons Public Domain Dedication waiver ( http://creativecommons.org/publicdomain/zero/1.0/) applies to the data made available in this article, unless otherwise stated.
spellingShingle Case Report
Ling, Helen
Kara, Eleanna
Revesz, Tamas
Lees, Andrew J
Plant, Gordon T
Martino, Davide
Houlden, Henry
Hardy, John
Holton, Janice L
Concomitant progressive supranuclear palsy and chronic traumatic encephalopathy in a boxer
title Concomitant progressive supranuclear palsy and chronic traumatic encephalopathy in a boxer
title_full Concomitant progressive supranuclear palsy and chronic traumatic encephalopathy in a boxer
title_fullStr Concomitant progressive supranuclear palsy and chronic traumatic encephalopathy in a boxer
title_full_unstemmed Concomitant progressive supranuclear palsy and chronic traumatic encephalopathy in a boxer
title_short Concomitant progressive supranuclear palsy and chronic traumatic encephalopathy in a boxer
title_sort concomitant progressive supranuclear palsy and chronic traumatic encephalopathy in a boxer
topic Case Report
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3996066/
https://www.ncbi.nlm.nih.gov/pubmed/24559032
http://dx.doi.org/10.1186/2051-5960-2-24
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