Cargando…

Lynch Syndrome from a surgeon perspective: retrospective study of clinical impact of mismatch repair protein expression analysis in colorectal cancer patients less than 50 years old

BACKGROUND: In clinical practice, unexpected diagnosis of colorectal cancer in young patients requires prompt surgery, thus genetic testing for Lynch Syndrome is frequently missed, and clinical management may result incorrect. METHODS: Patients younger than 50 years old undergoing colorectal resecti...

Descripción completa

Detalles Bibliográficos
Autores principales:	Baiocchi, Gian Luca, Portolani, Nazario, Vermi, William, Baronchelli, Carla, Gheza, Federico, Zogno, Claudio, Scaglia, Alessandro, Marchina, Eleonora, Tiberio, Guido AM, Giulini, Stefano Maria
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	BioMed Central 2014
Materias:	Research Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3996083/ https://www.ncbi.nlm.nih.gov/pubmed/24533633 http://dx.doi.org/10.1186/1471-2482-14-9

Ejemplares similares

Multiple primary malignancies of the liver and the colon: a complex diagnostic and decisional process with a final unanswered question
por: Portolani, Nazario, et al.
Publicado: (2014)

Intraductal papillary mucinous neoplasm of the pancreas (IPMN): clinico-pathological correlations and surgical indications
por: Baiocchi, Gian Luca, et al.
Publicado: (2010)

Parietal and peritoneal localizations of hepatocellular carcinoma: is there a place for a curative surgery?
por: Portolani, Nazario, et al.
Publicado: (2014)

Possible additional value of 18FDG-PET in managing pancreas intraductal papillary mucinous neoplasms: Preliminary results
por: Baiocchi, Gian Luca, et al.
Publicado: (2008)

Refractory hepatic lymphorrhea after total pancreatectomy. Case report and literature review of this uncommon complication
por: Bartoli, Michele, et al.
Publicado: (2015)

Gunshot wound without entrance hole: where is the trick? – a case report and review of the literaturer
por: Ministrini, Silvia, et al.
Publicado: (2015)

Differential expression profiling of long non-coding RNA GAS5 and miR-126-3p in human cancer cells in response to sorafenib
por: Faranda, Teresa, et al.
Publicado: (2019)

Pancreatic cancer ‘mismatch’ in Lynch syndrome
por: Hendifar, Andrew E, et al.
Publicado: (2019)

Recurrence in node-negative advanced gastric cancer: Novel findings from an in-depth pathological analysis of prognostic factors from a multicentric series
por: Baiocchi, Gian Luca, et al.
Publicado: (2017)

Hepatoblastoma of the adult with pericardial metastasis: A case report
por: Celotti, Andrea, et al.
Publicado: (2016)

Indocyanine-Green Fluorescence-GUIDED Liver Resection of Metastasis from Squamous Cell Carcinoma Invading the Biliary Tree
por: Benedicenti, Sara, et al.
Publicado: (2018)

Longitudinal Circulating Levels of miR-23b-3p, miR-126-3p and lncRNA GAS5 in HCC Patients Treated with Sorafenib
por: Manganelli, Michele, et al.
Publicado: (2021)

Frequent mismatch-repair defects link prostate cancer to Lynch syndrome
por: Dominguez-Valentin, Mev, et al.
Publicado: (2016)

Prevalence of Lynch syndrome in women with mismatch repair‐deficient ovarian cancer
por: Hodan, Rachel, et al.
Publicado: (2020)

Sporadic and Lynch syndrome-associated mismatch repair-deficient brain tumors
por: Kim, Hyunhee, et al.
Publicado: (2021)

Mismatch repair deficiency testing in Lynch syndrome-associated urothelial tumors
por: Rasmussen, Maria, et al.
Publicado: (2023)

Streamlining the use of IHC in identifying germline mismatch repair mutations in Lynch syndrome
por: Rea, Gillian, et al.
Publicado: (2012)

Hereditary Aspects of Colorectal Cancer: Mismatch Repair Genes Drive Lynch Syndrome
por: Hampel, Heather, et al.
Publicado: (2018)

Prevalence and Prognosis of Lynch Syndrome and Sporadic Mismatch Repair Deficiency in Endometrial Cancer
por: Post, Cathalijne C B, et al.
Publicado: (2021)

Challenges of Neoantigen Targeting in Lynch Syndrome and Constitutional Mismatch Repair Deficiency Syndrome
por: Abidi, Asima, et al.
Publicado: (2021)

Mismatch Repair Screening of Gastrointestinal Cancers: The Impact on Lynch Syndrome Detection and Immunotherapy
por: R., Openshaw M., et al.
Publicado: (2022)

Colorectal cancer incidences in Lynch syndrome: a comparison of results from the prospective lynch syndrome database and the international mismatch repair consortium
por: Møller, Pål, et al.
Publicado: (2022)

Immuno-Contexture and Immune Checkpoint Molecule Expression in Mismatch Repair Proficient Colorectal Carcinoma
por: Giacomelli, Mauro, et al.
Publicado: (2023)

Is it all Lynch Syndrome? An assessment of family history in individuals with mismatch repair deficient tumors
por: Dempsey, Katherine M., et al.
Publicado: (2014)

Mismatch repair gene mutations lead to lynch syndrome colorectal cancer in rhesus macaques
por: Dray, Beth K., et al.
Publicado: (2018)

Comprehensive mismatch repair gene panel identifies variants in patients with Lynch‐like syndrome
por: Xavier, Alexandre, et al.
Publicado: (2019)

Screening of Lynch syndrome in endometrial cancer in Iranian population with mismatch repair protein by immunohistochemistry
por: Noei Teymoordash, Somayyeh, et al.
Publicado: (2022)

The gate-keeping role of surgeons with regard to endometrial cancers in Lynch syndrome
por: Kim, Min Kyu
Publicado: (2017)

Mismatch Repair-Deficient Crypt Foci in Lynch Syndrome – Molecular Alterations and Association with Clinical Parameters
por: Staffa, Laura, et al.
Publicado: (2015)

Targeted next‐generation sequencing of 22 mismatch repair genes identifies Lynch syndrome families
por: Talseth‐Palmer, Bente A., et al.
Publicado: (2016)

Immunohistochemical Analysis of Mismatch Repair Proteins in Iranian Colorectal Cancer Patients at Risk for Lynch Syndrome
por: Zeinalian, Mehrdad, et al.
Publicado: (2015)

Prevalence of mismatch repair deficiency and Lynch syndrome in a cohort of unselected small bowel adenocarcinomas
por: Suerink, Manon, et al.
Publicado: (2021)

Indocyanine green fluorescence-guided intraoperative detection of peritoneal carcinomatosis: systematic review
por: Baiocchi, Gian Luca, et al.
Publicado: (2020)

Plasma EBV DNA as a prognostic factor in EBV associated gastric cancer: a multicenter, prospective study (EBV PRESAGE study)
por: Alberti, Andrea, et al.
Publicado: (2023)

TumorNext-Lynch-MMR: a comprehensive next generation sequencing assay for the detection of germline and somatic mutations in genes associated with mismatch repair deficiency and Lynch syndrome
por: Gray, Phillip N., et al.
Publicado: (2018)

Combined mismatch repair and POLE/POLD1 defects explain unresolved suspected Lynch syndrome cancers
por: Jansen, Anne ML, et al.
Publicado: (2016)

Association of Mismatch Repair Mutation With Age at Cancer Onset in Lynch Syndrome: Implications for Stratified Surveillance Strategies
por: Ryan, Neil A. J., et al.
Publicado: (2017)

Integrating Tumor Sequencing Into Clinical Practice for Patients With Mismatch Repair-Deficient Lynch Syndrome Spectrum Cancers
por: Dixon, Katherine, et al.
Publicado: (2021)

Tumor-independent Detection of Inherited Mismatch Repair Deficiency for the Diagnosis of Lynch Syndrome with High Specificity and Sensitivity
por: Kansikas, Minttu, et al.
Publicado: (2023)

Advanced Sealing and Dissecting Devices in Laparoscopic Adrenal Surgery
por: Solaini, Leonardo, et al.
Publicado: (2013)

Cannot write session to /tmp/vufind_sessions/sess_j0erumm06r09h923gbeanj5phk