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Adjuvant therapy for endometrial cancer

Endometrial cancer is a common gynecologic malignancy typically diagnosed at early stage and cured with surgery alone. Adjuvant therapy is tailored according to the risk of recurrence, estimated based on the International Federation of Gynecology and Obstetrics (FIGO) stage and other histological fa...

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Detalles Bibliográficos
Autores principales: DeLeon, Maria C., Ammakkanavar, Natraj R., Matei, Daniela
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Asian Society of Gynecologic Oncology; Korean Society of Gynecologic Oncology 2014
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3996264/
https://www.ncbi.nlm.nih.gov/pubmed/24761218
http://dx.doi.org/10.3802/jgo.2014.25.2.136
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author DeLeon, Maria C.
Ammakkanavar, Natraj R.
Matei, Daniela
author_facet DeLeon, Maria C.
Ammakkanavar, Natraj R.
Matei, Daniela
author_sort DeLeon, Maria C.
collection PubMed
description Endometrial cancer is a common gynecologic malignancy typically diagnosed at early stage and cured with surgery alone. Adjuvant therapy is tailored according to the risk of recurrence, estimated based on the International Federation of Gynecology and Obstetrics (FIGO) stage and other histological factors. The objective of this manuscript is to review the evidence guiding adjuvant therapy for early stage and locally advanced uterine cancer. For patients with early stage disease, minimizing toxicity, while preserving outstanding cure rates remains the major goal. For patients with locally advanced endometrial cancer optimal combined regimens are being defined. Risk stratification based on molecular traits is under development and may aid refine the current risk prediction model and permit personalized approaches for women with endometrial cancer.
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spelling pubmed-39962642014-04-23 Adjuvant therapy for endometrial cancer DeLeon, Maria C. Ammakkanavar, Natraj R. Matei, Daniela J Gynecol Oncol Review Article Endometrial cancer is a common gynecologic malignancy typically diagnosed at early stage and cured with surgery alone. Adjuvant therapy is tailored according to the risk of recurrence, estimated based on the International Federation of Gynecology and Obstetrics (FIGO) stage and other histological factors. The objective of this manuscript is to review the evidence guiding adjuvant therapy for early stage and locally advanced uterine cancer. For patients with early stage disease, minimizing toxicity, while preserving outstanding cure rates remains the major goal. For patients with locally advanced endometrial cancer optimal combined regimens are being defined. Risk stratification based on molecular traits is under development and may aid refine the current risk prediction model and permit personalized approaches for women with endometrial cancer. Asian Society of Gynecologic Oncology; Korean Society of Gynecologic Oncology 2014-04 2014-04-09 /pmc/articles/PMC3996264/ /pubmed/24761218 http://dx.doi.org/10.3802/jgo.2014.25.2.136 Text en Copyright © 2014. Asian Society of Gynecologic Oncology, Korean Society of Gynecologic Oncology http://creativecommons.org/licenses/by-nc/3.0/ This is an Open Access article distributed under the terms of the Creative Commons Attribution Non-Commercial License (http://creativecommons.org/licenses/by-nc/3.0/) which permits unrestricted non-commercial use, distribution, and reproduction in any medium, provided the original work is properly cited.
spellingShingle Review Article
DeLeon, Maria C.
Ammakkanavar, Natraj R.
Matei, Daniela
Adjuvant therapy for endometrial cancer
title Adjuvant therapy for endometrial cancer
title_full Adjuvant therapy for endometrial cancer
title_fullStr Adjuvant therapy for endometrial cancer
title_full_unstemmed Adjuvant therapy for endometrial cancer
title_short Adjuvant therapy for endometrial cancer
title_sort adjuvant therapy for endometrial cancer
topic Review Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3996264/
https://www.ncbi.nlm.nih.gov/pubmed/24761218
http://dx.doi.org/10.3802/jgo.2014.25.2.136
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