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Facing Contrast-Enhancing Gliomas: Perfusion MRI in Grade III and Grade IV Gliomas according to Tumor Area

Tumoral neoangiogenesis characterizes high grade gliomas. Relative Cerebral Blood Volume (rCBV), calculated with Dynamic Susceptibility Contrast (DSC) Perfusion-Weighted Imaging (PWI), allows for the estimation of vascular density over the tumor bed. The aim of the study was to characterize putative...

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Autores principales: Di Stefano, Anna Luisa, Bergsland, Niels, Berzero, Giulia, Farina, Lisa, Rognone, Elisa, Gastaldi, Matteo, Aquino, Domenico, Frati, Alessandro, Tomasello, Francesco, Ceroni, Mauro, Marchioni, Enrico, Bastianello, Stefano
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Hindawi Publishing Corporation 2014
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3996293/
https://www.ncbi.nlm.nih.gov/pubmed/24800207
http://dx.doi.org/10.1155/2014/154350
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author Di Stefano, Anna Luisa
Bergsland, Niels
Berzero, Giulia
Farina, Lisa
Rognone, Elisa
Gastaldi, Matteo
Aquino, Domenico
Frati, Alessandro
Tomasello, Francesco
Ceroni, Mauro
Marchioni, Enrico
Bastianello, Stefano
author_facet Di Stefano, Anna Luisa
Bergsland, Niels
Berzero, Giulia
Farina, Lisa
Rognone, Elisa
Gastaldi, Matteo
Aquino, Domenico
Frati, Alessandro
Tomasello, Francesco
Ceroni, Mauro
Marchioni, Enrico
Bastianello, Stefano
author_sort Di Stefano, Anna Luisa
collection PubMed
description Tumoral neoangiogenesis characterizes high grade gliomas. Relative Cerebral Blood Volume (rCBV), calculated with Dynamic Susceptibility Contrast (DSC) Perfusion-Weighted Imaging (PWI), allows for the estimation of vascular density over the tumor bed. The aim of the study was to characterize putative tumoral neoangiogenesis via the study of maximal rCBV with a Region of Interest (ROI) approach in three tumor areas—the contrast-enhancing area, the nonenhancing tumor, and the high perfusion area on CBV map—in patients affected by contrast-enhancing glioma (grades III and IV). Twenty-one patients were included: 15 were affected by grade IV and 6 by grade III glioma. Maximal rCBV values for each patient were averaged according to glioma grade. Although rCBV from contrast-enhancement and from nonenhancing tumor areas was higher in grade IV glioma than in grade III (5.58 and 2.68; 3.01 and 2.2, resp.), the differences were not significant. Instead, rCBV recorded in the high perfusion area on CBV map, independently of tumor compartment, was significantly higher in grade IV glioma than in grade III (7.51 versus 3.78, P = 0.036). In conclusion, neoangiogenesis encompasses different tumor compartments and CBV maps appear capable of best characterizing the degree of neovascularization. Facing contrast-enhancing brain tumors, areas of high perfusion on CBV maps should be considered as the reference areas to be targeted for glioma grading.
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spelling pubmed-39962932014-05-05 Facing Contrast-Enhancing Gliomas: Perfusion MRI in Grade III and Grade IV Gliomas according to Tumor Area Di Stefano, Anna Luisa Bergsland, Niels Berzero, Giulia Farina, Lisa Rognone, Elisa Gastaldi, Matteo Aquino, Domenico Frati, Alessandro Tomasello, Francesco Ceroni, Mauro Marchioni, Enrico Bastianello, Stefano Biomed Res Int Clinical Study Tumoral neoangiogenesis characterizes high grade gliomas. Relative Cerebral Blood Volume (rCBV), calculated with Dynamic Susceptibility Contrast (DSC) Perfusion-Weighted Imaging (PWI), allows for the estimation of vascular density over the tumor bed. The aim of the study was to characterize putative tumoral neoangiogenesis via the study of maximal rCBV with a Region of Interest (ROI) approach in three tumor areas—the contrast-enhancing area, the nonenhancing tumor, and the high perfusion area on CBV map—in patients affected by contrast-enhancing glioma (grades III and IV). Twenty-one patients were included: 15 were affected by grade IV and 6 by grade III glioma. Maximal rCBV values for each patient were averaged according to glioma grade. Although rCBV from contrast-enhancement and from nonenhancing tumor areas was higher in grade IV glioma than in grade III (5.58 and 2.68; 3.01 and 2.2, resp.), the differences were not significant. Instead, rCBV recorded in the high perfusion area on CBV map, independently of tumor compartment, was significantly higher in grade IV glioma than in grade III (7.51 versus 3.78, P = 0.036). In conclusion, neoangiogenesis encompasses different tumor compartments and CBV maps appear capable of best characterizing the degree of neovascularization. Facing contrast-enhancing brain tumors, areas of high perfusion on CBV maps should be considered as the reference areas to be targeted for glioma grading. Hindawi Publishing Corporation 2014 2014-04-03 /pmc/articles/PMC3996293/ /pubmed/24800207 http://dx.doi.org/10.1155/2014/154350 Text en Copyright © 2014 Anna Luisa Di Stefano et al. https://creativecommons.org/licenses/by/3.0/ This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.
spellingShingle Clinical Study
Di Stefano, Anna Luisa
Bergsland, Niels
Berzero, Giulia
Farina, Lisa
Rognone, Elisa
Gastaldi, Matteo
Aquino, Domenico
Frati, Alessandro
Tomasello, Francesco
Ceroni, Mauro
Marchioni, Enrico
Bastianello, Stefano
Facing Contrast-Enhancing Gliomas: Perfusion MRI in Grade III and Grade IV Gliomas according to Tumor Area
title Facing Contrast-Enhancing Gliomas: Perfusion MRI in Grade III and Grade IV Gliomas according to Tumor Area
title_full Facing Contrast-Enhancing Gliomas: Perfusion MRI in Grade III and Grade IV Gliomas according to Tumor Area
title_fullStr Facing Contrast-Enhancing Gliomas: Perfusion MRI in Grade III and Grade IV Gliomas according to Tumor Area
title_full_unstemmed Facing Contrast-Enhancing Gliomas: Perfusion MRI in Grade III and Grade IV Gliomas according to Tumor Area
title_short Facing Contrast-Enhancing Gliomas: Perfusion MRI in Grade III and Grade IV Gliomas according to Tumor Area
title_sort facing contrast-enhancing gliomas: perfusion mri in grade iii and grade iv gliomas according to tumor area
topic Clinical Study
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3996293/
https://www.ncbi.nlm.nih.gov/pubmed/24800207
http://dx.doi.org/10.1155/2014/154350
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