Dopamine Cytotoxicity Involves Both Oxidative and Nonoxidative Pathways in SH-SY5Y Cells: Potential Role of Alpha-Synuclein Overexpression and Proteasomal Inhibition in the Etiopathogenesis of Parkinson's Disease

Background. The cytotoxic effects of dopamine (DA) on several catecholaminergic cell lines involve DA oxidation products like reactive oxygen species (ROS) and toxic quinones and have implications in the pathogenesis of sporadic Parkinson's disease (PD). However, many molecular details are yet...

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Detalles Bibliográficos
Autores principales: Banerjee, Kalpita, Munshi, Soumyabrata, Sen, Oishimaya, Pramanik, Vishmadeb, Roy Mukherjee, Tapasi, Chakrabarti, Sasanka
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Hindawi Publishing Corporation 2014
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3996320/
https://www.ncbi.nlm.nih.gov/pubmed/24804146
http://dx.doi.org/10.1155/2014/878935

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3996320/
https://www.ncbi.nlm.nih.gov/pubmed/24804146
http://dx.doi.org/10.1155/2014/878935

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