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Periconception Weight Loss: Common Sense for Mothers, but What about for Babies?

Obesity in the childbearing population is increasingly common. Obesity is associated with increased risk for a number of maternal and neonatal pregnancy complications. Some of these complications, such as gestational diabetes, are risk factors for long-term disease in both mother and baby. While cli...

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Autores principales: Matusiak, Kristine, Barrett, Helen L., Callaway, Leonie K., Nitert, Marloes Dekker
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Hindawi Publishing Corporation 2014
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3996361/
https://www.ncbi.nlm.nih.gov/pubmed/24804085
http://dx.doi.org/10.1155/2014/204295
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author Matusiak, Kristine
Barrett, Helen L.
Callaway, Leonie K.
Nitert, Marloes Dekker
author_facet Matusiak, Kristine
Barrett, Helen L.
Callaway, Leonie K.
Nitert, Marloes Dekker
author_sort Matusiak, Kristine
collection PubMed
description Obesity in the childbearing population is increasingly common. Obesity is associated with increased risk for a number of maternal and neonatal pregnancy complications. Some of these complications, such as gestational diabetes, are risk factors for long-term disease in both mother and baby. While clinical practice guidelines advocate for healthy weight prior to pregnancy, there is not a clear directive for achieving healthy weight before conception. There are known benefits to even moderate weight loss prior to pregnancy, but there are potential adverse effects of restricted nutrition during the periconceptional period. Epidemiological and animal studies point to differences in offspring conceived during a time of maternal nutritional restriction. These include changes in hypothalamic-pituitary-adrenal axis function, body composition, glucose metabolism, and cardiovascular function. The periconceptional period is therefore believed to play an important role in programming offspring physiological function and is sensitive to nutritional insult. This review summarizes the evidence to date for offspring programming as a result of maternal periconception weight loss. Further research is needed in humans to clearly identify benefits and potential risks of losing weight in the months before conceiving. This may then inform us of clinical practice guidelines for optimal approaches to achieving a healthy weight before pregnancy.
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spelling pubmed-39963612014-05-06 Periconception Weight Loss: Common Sense for Mothers, but What about for Babies? Matusiak, Kristine Barrett, Helen L. Callaway, Leonie K. Nitert, Marloes Dekker J Obes Review Article Obesity in the childbearing population is increasingly common. Obesity is associated with increased risk for a number of maternal and neonatal pregnancy complications. Some of these complications, such as gestational diabetes, are risk factors for long-term disease in both mother and baby. While clinical practice guidelines advocate for healthy weight prior to pregnancy, there is not a clear directive for achieving healthy weight before conception. There are known benefits to even moderate weight loss prior to pregnancy, but there are potential adverse effects of restricted nutrition during the periconceptional period. Epidemiological and animal studies point to differences in offspring conceived during a time of maternal nutritional restriction. These include changes in hypothalamic-pituitary-adrenal axis function, body composition, glucose metabolism, and cardiovascular function. The periconceptional period is therefore believed to play an important role in programming offspring physiological function and is sensitive to nutritional insult. This review summarizes the evidence to date for offspring programming as a result of maternal periconception weight loss. Further research is needed in humans to clearly identify benefits and potential risks of losing weight in the months before conceiving. This may then inform us of clinical practice guidelines for optimal approaches to achieving a healthy weight before pregnancy. Hindawi Publishing Corporation 2014 2014-04-02 /pmc/articles/PMC3996361/ /pubmed/24804085 http://dx.doi.org/10.1155/2014/204295 Text en Copyright © 2014 Kristine Matusiak et al. https://creativecommons.org/licenses/by/3.0/ This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.
spellingShingle Review Article
Matusiak, Kristine
Barrett, Helen L.
Callaway, Leonie K.
Nitert, Marloes Dekker
Periconception Weight Loss: Common Sense for Mothers, but What about for Babies?
title Periconception Weight Loss: Common Sense for Mothers, but What about for Babies?
title_full Periconception Weight Loss: Common Sense for Mothers, but What about for Babies?
title_fullStr Periconception Weight Loss: Common Sense for Mothers, but What about for Babies?
title_full_unstemmed Periconception Weight Loss: Common Sense for Mothers, but What about for Babies?
title_short Periconception Weight Loss: Common Sense for Mothers, but What about for Babies?
title_sort periconception weight loss: common sense for mothers, but what about for babies?
topic Review Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3996361/
https://www.ncbi.nlm.nih.gov/pubmed/24804085
http://dx.doi.org/10.1155/2014/204295
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