CXCL12 in astrocytes contributes to bone cancer pain through CXCR4-mediated neuronal sensitization and glial activation in rat spinal cord

BACKGROUND: Previous studies have demonstrated that chemokine CXCL12 and its receptor CXCR4 are critical for pain sensitization, but the mechanisms involved are not clear. In this study, we investigated the specific cellular mechanisms of CXCL12/CXCR4 chemokine signaling in the development and maint...

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Detalles Bibliográficos
Autores principales: Shen, Wen, Hu, Xue-Ming, Liu, Yan-Nan, Han, Yuan, Chen, Li-Ping, Wang, Chen-Chen, Song, Chao
Formato: Online Artículo Texto
Lenguaje:English
Publicado: BioMed Central 2014
Materias:
Research
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3996502/
https://www.ncbi.nlm.nih.gov/pubmed/24735601
http://dx.doi.org/10.1186/1742-2094-11-75

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