Cargando…

Polycomb proteins control proliferation and transformation independently of cell cycle checkpoints by regulating DNA replication

The ability of PRC1 and PRC2 to promote proliferation is a main feature that links polycomb (PcG) activity to cancer. PcGs silence the expression of the tumour suppressor locus Ink4a/Arf, whose products positively regulate pRb and p53 functions. Enhanced PcG activity is a frequent feature of human t...

Descripción completa

Detalles Bibliográficos
Autores principales:	Piunti, Andrea, Rossi, Alessandra, Cerutti, Aurora, Albert, Mareike, Jammula, Sriganesh, Scelfo, Andrea, Cedrone, Laura, Fragola, Giulia, Olsson, Linda, Koseki, Haruhiko, Testa, Giuseppe, Casola, Stefano, Helin, Kristian, di Fagagna, Fabrizio d’Adda, Pasini, Diego
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Nature Pub. Group 2014
Materias:	Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3996544/ https://www.ncbi.nlm.nih.gov/pubmed/24728135 http://dx.doi.org/10.1038/ncomms4649

Ejemplares similares

Maintenance of leukemic cell identity by the activity of the Polycomb complex PRC1 in mice
por: Rossi, Alessandra, et al.
Publicado: (2016)

The cohesin complex prevents Myc-induced replication stress
por: Rohban, Sara, et al.
Publicado: (2017)

A Novel Zinc Finger Protein Zfp277 Mediates Transcriptional Repression of the Ink4a/Arf Locus through Polycomb Repressive Complex 1
por: Negishi, Masamitsu, et al.
Publicado: (2010)

The Polycomb Repressive Complex 2 Is a Potential Target of SUMO Modifications
por: Riising, Eva Madi, et al.
Publicado: (2008)

Never-ageing cellular senescence
por: Ogrunc, Müge, et al.
Publicado: (2011)

Neural stem cells exposed to BrdU lose their global DNA methylation and undergo astrocytic differentiation
por: Schneider, Leonid, et al.
Publicado: (2012)

Detection of Telomeric DNA:RNA Hybrids Using TeloDRIP-qPCR
por: Rosso, Ilaria, et al.
Publicado: (2020)

EpiMINE, a computational program for mining epigenomic data
por: Jammula, SriGanesh, et al.
Publicado: (2016)

Cell Reprogramming Requires Silencing of a Core Subset of Polycomb Targets
por: Fragola, Giulia, et al.
Publicado: (2013)

Polycomb group ring finger protein 6 suppresses Myc-induced lymphomagenesis
por: Tanaskovic, Nina, et al.
Publicado: (2022)

Need telomere maintenance? Call 911
por: Francia, Sofia, et al.
Publicado: (2007)

NOTCH1 Inhibits Activation of ATM by Impairing the Formation of an ATM-FOXO3a-KAT5/Tip60 Complex
por: Adamowicz, Marek, et al.
Publicado: (2016)

A novel single‐cell method provides direct evidence of persistent DNA damage in senescent cells and aged mammalian tissues
por: Galbiati, Alessandro, et al.
Publicado: (2017)

Stable Cellular Senescence Is Associated with Persistent DDR Activation
por: Fumagalli, Marzia, et al.
Publicado: (2014)

Characterization of an antagonistic switch between histone H3 lysine 27 methylation and acetylation in the transcriptional regulation of Polycomb group target genes
por: Pasini, Diego, et al.
Publicado: (2010)

Correction to ‘Characterization of an antagonistic switch between histone H3 lysine 27 methylation and acetylation in the transcriptional regulation of Polycomb group target genes’
por: Pasini, Diego, et al.
Publicado: (2021)

DICER, DROSHA and DNA damage response RNAs are necessary for the secondary recruitment of DNA damage response factors
por: Francia, Sofia, et al.
Publicado: (2016)

Irreparable telomeric DNA damage and persistent DDR signalling as a shared causative mechanism of cellular senescence and ageing
por: Rossiello, Francesca, et al.
Publicado: (2014)

The Polycomb group protein Ring1 regulates dorsoventral patterning of the mouse telencephalon
por: Eto, Hikaru, et al.
Publicado: (2020)

Synergy between Variant PRC1 Complexes Defines Polycomb-Mediated Gene Repression
por: Fursova, Nadezda A., et al.
Publicado: (2019)

DNA Damage in Mammalian Neural Stem Cells Leads to Astrocytic Differentiation Mediated by BMP2 Signaling through JAK-STAT
por: Schneider, Leonid, et al.
Publicado: (2013)

Polycomb directs timely activation of germline genes in spermatogenesis
por: Maezawa, So, et al.
Publicado: (2017)

PREP1 tumor suppressor protects the late-replicating DNA by controlling its replication timing and symmetry
por: Palmigiano, Angela, et al.
Publicado: (2018)

Polycomb Repressive Complex 1 Controls Maintenance of Fungiform Papillae by Repressing Sonic Hedgehog Expression
por: Bar, Carmit, et al.
Publicado: (2019)

Corrigendum: The Polycomb group proteins bind throughout the INK4A-ARF locus and are disassociated in senescent cells
por: Bracken, Adrian P., et al.
Publicado: (2023)

A polycomb group protein, PHF1, is involved in the response to DNA double-strand breaks in human cell
por: Hong, Zehui, et al.
Publicado: (2008)

Polycomb complexes redundantly maintain epidermal stem cell identity during development
por: Cohen, Idan, et al.
Publicado: (2021)

Conversion of T cells to B cells by inactivation of polycomb-mediated epigenetic suppression of the B-lineage program
por: Ikawa, Tomokatsu, et al.
Publicado: (2016)

Oncogene-induced telomere dysfunction enforces cellular senescence in human cancer precursor lesions
por: Suram, Anitha, et al.
Publicado: (2012)

DNA damage response inhibition at dysfunctional telomeres by modulation of telomeric DNA damage response RNAs
por: Rossiello, Francesca, et al.
Publicado: (2017)

Corrigendum: DNA damage response inhibition at dysfunctional telomeres by modulation of telomeric DNA damage response RNAs
por: Rossiello, Francesca, et al.
Publicado: (2017)

Pharmacological boost of DNA damage response and repair by enhanced biogenesis of DNA damage response RNAs
por: Gioia, Ubaldo, et al.
Publicado: (2019)

Telomerase abrogates aneuploidy-induced telomere replication stress, senescence and cell depletion
por: Meena, Jitendra K, et al.
Publicado: (2015)

Ash1l Methylates Lys36 of Histone H3 Independently of Transcriptional Elongation to Counteract Polycomb Silencing
por: Miyazaki, Hitomi, et al.
Publicado: (2013)

Oncogene-induced reactive oxygen species fuel hyperproliferation and DNA damage response activation
por: Ogrunc, M, et al.
Publicado: (2014)

Resection is responsible for loss of transcription around a double-strand break in Saccharomyces cerevisiae
por: Manfrini, Nicola, et al.
Publicado: (2015)

DROSHA is recruited to DNA damage sites by the MRN complex to promote non-homologous end joining
por: Cabrini, Matteo, et al.
Publicado: (2021)

Polycomb repressive complex 1.1 coordinates homeostatic and emergency myelopoiesis
por: Nakajima-Takagi, Yaeko, et al.
Publicado: (2023)

Site-specific DICER and DROSHA RNA products control the DNA damage response
por: Francia, Sofia, et al.
Publicado: (2012)

Polycomb Group Protein Ezh2 Regulates Hepatic Progenitor Cell Proliferation and Differentiation in Murine Embryonic Liver
por: Koike, Hiroyuki, et al.
Publicado: (2014)

Cannot write session to /tmp/vufind_sessions/sess_naigshv7aq5ijh98bevikm40lv