PHLPP2 suppresses the NF-κB pathway by inactivating IKKβ kinase

The NF-κB growth pathway is constitutively activated in many cancers but its activation mechanism is unclear in most cases. We show that PHLPP2 interacts with IKKβ kinase, decreases its phosphorylation and the subsequent NF-κB activation in cancer cells. PHLPP2 is progressively lost in glioma and co...

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Detalles Bibliográficos
Autores principales: Agarwal, Nitin Kumar, Zhu, Xiaoping, Gagea, Mihai, White, Charles L., Cote, Gilbert, Georgescu, Maria-Magdalena
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Impact Journals LLC 2014
Materias:
Research Paper
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3996652/
https://www.ncbi.nlm.nih.gov/pubmed/24553260

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3996652/
https://www.ncbi.nlm.nih.gov/pubmed/24553260

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