Cytotoxic effects of 15d-PGJ2 against osteosarcoma through ROS-mediated AKT and cell cycle inhibition

Polo-like kinase 1 (PLK1), a critical cell cycle regulator, has been identified as a potential target in osteosarcoma (OS). 15-deoxy-Δ12, 14-prostaglandin J2 (15d-PGJ2), a prostaglandin derivative, has shown its anti-tumor activity by inducing apoptosis through reactive oxygen species (ROS)-mediated...

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Detalles Bibliográficos
Autores principales: Yen, Chueh-Chuan, Hsiao, Chung-Der, Chen, Wei-Ming, Wen, Yao-Shan, Lin, Yung-Chan, Chang, Ting-Wei, Yao, Fang-Yi, Hung, Shih-Chieh, Wang, Jir-You, Chiu, Jen-Hwey, Wang, Hsei-Wei, Lin, Chi-Hung, Chen, Tain-Hsiung, Chen, Paul Chih-Hsueh, Liu, Chien-Lin, Tzeng, Cheng-Hwai, Fletcher, Jonathan A.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Impact Journals LLC 2014
Materias:
Research Paper
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3996657/
https://www.ncbi.nlm.nih.gov/pubmed/24566468

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