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AKT mediates actinomycin D-induced p53 expression

At high cytotoxic concentrations, actinomycin D (ActD) blocks transcription, decreasing levels of MDM2 and thus causing p53 stabilization. At low cytostatic concentrations, ActD causes ribosomal stress, which decreases MDM2 activity, resulting in p53 stabilization and activation. ActD can thus be us...

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Detalles Bibliográficos
Autores principales:	Chen, Chih-Shou, Ho, Dong-Ru, Chen, Fei-Yun, Chen, Chang-Rong, Ke, Yu-De, Su, Jyan-Gwo Joseph
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Impact Journals LLC 2014
Materias:	Research Paper
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3996664/ https://www.ncbi.nlm.nih.gov/pubmed/24525337

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