Cargando…

LIF promotes tumorigenesis and metastasis of breast cancer through the AKT-mTOR pathway

Leukemia inhibitory factor (LIF) is a multi-functional cytokine protein. The role of LIF in tumorigenesis is not well-understood. Here, we found that LIF promotes tumorigenesis and metastasis of breast cancer. LIF promotes cell proliferation and anchorage-independent growth of breast cancer cells in...

Descripción completa

Detalles Bibliográficos
Autores principales:	Li, Xiaoyan, Yang, Qifeng, Yu, Haiyang, Wu, Lihua, Zhao, Yuhan, Zhang, Cen, Yue, Xuetian, Liu, Zhen, Wu, Hao, Haffty, Bruce G., Feng, Zhaohui, Hu, Wenwei
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Impact Journals LLC 2014
Materias:	Research Paper
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3996668/ https://www.ncbi.nlm.nih.gov/pubmed/24553191

Ejemplares similares

HIF-2α mediates hypoxia-induced LIF expression in human colorectal cancer cells
por: Wu, Lihua, et al.
Publicado: (2015)

LIF negatively regulates tumor suppressor p53 through Stat3/ID1/MDM2 in colorectal cancers
por: Yu, Haiyang, et al.
Publicado: (2014)

LIF is essential for ISC function and protects against radiation-induced gastrointestinal syndrome
por: Wang, Huaying, et al.
Publicado: (2020)

Glutaminase 2 is a novel negative regulator of small GTPase Rac1 and mediates p53 function in suppressing metastasis
por: Zhang, Cen, et al.
Publicado: (2016)

BAG2 promotes tumorigenesis through enhancing mutant p53 protein levels and function
por: Yue, Xuetian, et al.
Publicado: (2015)

Cullin3–KLHL25 ubiquitin ligase targets ACLY for degradation to inhibit lipid synthesis and tumor progression
por: Zhang, Cen, et al.
Publicado: (2016)

MYC Cooperates with AKT in Prostate Tumorigenesis and Alters Sensitivity to mTOR Inhibitors
por: Clegg, Nicola J., et al.
Publicado: (2011)

EC330, a small-molecule compound, is a potential novel inhibitor of LIF signaling
por: Yue, Xuetian, et al.
Publicado: (2020)

A novel mutant p53 binding partner BAG5 stabilizes mutant p53 and promotes mutant p53 GOFs in tumorigenesis
por: Yue, Xuetian, et al.
Publicado: (2016)

microRNA-1827 represses MDM2 to positively regulate tumor suppressor p53 and suppress tumorigenesis
por: Zhang, Cen, et al.
Publicado: (2016)

A polymorphism in the tumor suppressor p53 affects aging and longevity in mouse models
por: Zhao, Yuhan, et al.
Publicado: (2018)

Parkin targets HIF-1α for ubiquitination and degradation to inhibit breast tumor progression
por: Liu, Juan, et al.
Publicado: (2017)

Spliced MDM2 isoforms promote mutant p53 accumulation and gain-of-function in tumorigenesis
por: Zheng, Tongsen, et al.
Publicado: (2013)

The Paradox of Akt-mTOR Interactions
por: Vadlakonda, Lakshmipathi, et al.
Publicado: (2013)

Regulation of Osteoclast Growth and Fusion by mTOR/raptor and mTOR/rictor/Akt
por: Tiedemann, Kerstin, et al.
Publicado: (2017)

Leukemia inhibitory factor promotes EMT through STAT3-dependent miR-21 induction
por: Yue, Xuetian, et al.
Publicado: (2015)

xCT contributes to colorectal cancer tumorigenesis through upregulation of the MELK oncogene and activation of the AKT/mTOR cascade
por: Tang, Bufu, et al.
Publicado: (2022)

GLUD1 suppresses renal tumorigenesis and development via inhibiting PI3K/Akt/mTOR pathway
por: Wang, Lei, et al.
Publicado: (2022)

Targeting tumorigenesis: development and use of mTOR inhibitors in cancer therapy
por: Yuan, RuiRong, et al.
Publicado: (2009)

Suppression of Akt-mTOR Pathway-A Novel Component of Oncogene Induced DNA Damage Response Barrier in Breast Tumorigenesis
por: Bhardwaj, Anjana, et al.
Publicado: (2014)

Growth factor progranulin promotes tumorigenesis of cervical cancer via PI3K/Akt/mTOR signaling pathway
por: Feng, Tingting, et al.
Publicado: (2016)

Akt and mTOR in B Cell Activation and Differentiation
por: Limon, Jose J., et al.
Publicado: (2012)

Akt and mTOR mediate programmed necrosis in neurons
por: Liu, Q, et al.
Publicado: (2014)

SLFN11 inhibits hepatocellular carcinoma tumorigenesis and metastasis by targeting RPS4X via mTOR pathway
por: Zhou, Chenhao, et al.
Publicado: (2020)

FOXK1 Promotes Proliferation and Metastasis of Gallbladder Cancer by Activating AKT/mTOR Signaling Pathway
por: Wencong, Ma, et al.
Publicado: (2020)

Inhibition of the AKT/mTOR pathway negatively regulates PTEN expression via miRNAs: Effect of Akt/mTOR inhibition on PTEN expression
por: Wan, Linyan, et al.
Publicado: (2022)

Knockdown of lncRNA TDRG1 Inhibits Tumorigenesis in Endometrial Carcinoma Through the PI3K/AKT/mTOR Pathway
por: Sun, Ruimei, et al.
Publicado: (2019)

STIL Promotes Tumorigenesis of Bladder Cancer by Activating PI3K/AKT/mTOR Signaling Pathway and Targeting C-Myc
por: Yu, Hua, et al.
Publicado: (2022)

Matrine exerts antitumor activity in cervical cancer by protective autophagy via the Akt/mTOR pathway in vitro and in vivo
por: Zhang, Fan, et al.
Publicado: (2022)

PI3K/AKT/mTOR-Targeted Therapy for Breast Cancer
por: Zhu, Kunrui, et al.
Publicado: (2022)

TSSC3 promotes autophagy via inactivating the Src-mediated PI3K/Akt/mTOR pathway to suppress tumorigenesis and metastasis in osteosarcoma, and predicts a favorable prognosis
por: Zhao, Guo-sheng, et al.
Publicado: (2018)

Effect of activation of the Akt/mTOR signaling pathway by EEF1A2 on the biological behavior of osteosarcoma
por: Yang, Jianing, et al.
Publicado: (2021)

PI3K/AKT/mTOR Pathway in Angiogenesis
por: Karar, Jayashree, et al.
Publicado: (2011)

S100 calcium-binding protein A10 contributes to malignant traits in osteosarcoma cells by regulating glycolytic metabolism via the AKT/mTOR pathway
por: Ling, Feng, et al.
Publicado: (2022)

Elevation of CD109 promotes metastasis and drug resistance in lung cancer via activation of EGFR‐AKT‐mTOR signaling
por: Lee, Kang‐Yun, et al.
Publicado: (2020)

Bufalin suppresses hepatocellular carcinoma invasion and metastasis by targeting HIF-1α via the PI3K/AKT/mTOR pathway
por: Wang, Haiyong, et al.
Publicado: (2016)

Baicalein inhibits prostate cancer cell growth and metastasis via the caveolin-1/AKT/mTOR pathway
por: Guo, Zhaoxin, et al.
Publicado: (2015)

Peroxiredoxin-1 promotes cell proliferation and metastasis through enhancing Akt/mTOR in human osteosarcoma cells
por: Cai, An-Lie, et al.
Publicado: (2017)

BSCI-11. Targeting PI3K/Akt/mTOR pathway to prevent melanoma brain metastasis
por: Tehranian, Cedric, et al.
Publicado: (2021)

Osteopontin is Critical for Hyperactive mTOR-Induced Tumorigenesis in Oral Squamous Cell Carcinoma
por: Gan, Ning, et al.
Publicado: (2017)

Cannot write session to /tmp/vufind_sessions/sess_cr7dl1cae8td5caea42fsnku1t