MUC1-C nuclear localization drives invasiveness of renal cancer cells through a sheddase/gamma secretase dependent pathway

MUC1 is a membrane-anchored mucin and its cytoplasmic tail (CT) can interact with many signaling pathways and act as a co-transcription factor to activate genes involved in tumor progression and metastasis. MUC1 is overexpressed in renal cell carcinoma with correlation to prognosis and has been impl...

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Detalles Bibliográficos
Autores principales: Bouillez, Audrey, Gnemmi, Viviane, Gaudelot, Kelly, Hémon, Brigitte, Ringot, Bélinda, Pottier, Nicolas, Glowacki, François, Butruille, Caroline, Cauffiez, Christelle, Hamdane, Malika, Sergeant, Nicolas, Seuningen, Isabelle Van, Leroy, Xavier, Aubert, Sébastien, Perrais, Michaël
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Impact Journals LLC 2014
Materias:
Research Paper
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3996672/
https://www.ncbi.nlm.nih.gov/pubmed/24504508

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