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Dynamics of High-Risk Nonvaccine Human Papillomavirus Types after Actual Vaccination Scheme
Human papillomavirus (HPV) has been identified as the main etiological factor in the developing of cervical cancer (CC). This finding has propitiated the development of vaccines that help to prevent the HPVs 16 and 18 infection. Both genotypes are associated with 70% of CC worldwide. In the present...
Autores principales: | , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Hindawi Publishing Corporation
2014
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3996882/ https://www.ncbi.nlm.nih.gov/pubmed/24803952 http://dx.doi.org/10.1155/2014/542923 |
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author | Peralta, Raúl Vargas-De-León, Cruz Cabrera, Augusto Miramontes, Pedro |
author_facet | Peralta, Raúl Vargas-De-León, Cruz Cabrera, Augusto Miramontes, Pedro |
author_sort | Peralta, Raúl |
collection | PubMed |
description | Human papillomavirus (HPV) has been identified as the main etiological factor in the developing of cervical cancer (CC). This finding has propitiated the development of vaccines that help to prevent the HPVs 16 and 18 infection. Both genotypes are associated with 70% of CC worldwide. In the present study, we aimed to determine the emergence of high-risk nonvaccine HPV after actual vaccination scheme to estimate the impact of the current HPV vaccines. A SIR-type model was used to study the HPV dynamics after vaccination. According to the results, our model indicates that the application of the vaccine reduces infection by target or vaccine genotypes as expected. However, numerical simulations of the model suggest the presence of the phenomenon called vaccine—induced pathogen strain replacement. Here, we report the following replacement mechanism: if the effectiveness of cross-protective immunity is not larger than the effectiveness of the vaccine, then the high-risk nonvaccine genotypes emerge. In this scenario, further studies of infection dispersion by HPV are necessary to ascertain the real impact of the current vaccines, primarily because of the different high-risk HPV types that are found in CC. |
format | Online Article Text |
id | pubmed-3996882 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2014 |
publisher | Hindawi Publishing Corporation |
record_format | MEDLINE/PubMed |
spelling | pubmed-39968822014-05-06 Dynamics of High-Risk Nonvaccine Human Papillomavirus Types after Actual Vaccination Scheme Peralta, Raúl Vargas-De-León, Cruz Cabrera, Augusto Miramontes, Pedro Comput Math Methods Med Research Article Human papillomavirus (HPV) has been identified as the main etiological factor in the developing of cervical cancer (CC). This finding has propitiated the development of vaccines that help to prevent the HPVs 16 and 18 infection. Both genotypes are associated with 70% of CC worldwide. In the present study, we aimed to determine the emergence of high-risk nonvaccine HPV after actual vaccination scheme to estimate the impact of the current HPV vaccines. A SIR-type model was used to study the HPV dynamics after vaccination. According to the results, our model indicates that the application of the vaccine reduces infection by target or vaccine genotypes as expected. However, numerical simulations of the model suggest the presence of the phenomenon called vaccine—induced pathogen strain replacement. Here, we report the following replacement mechanism: if the effectiveness of cross-protective immunity is not larger than the effectiveness of the vaccine, then the high-risk nonvaccine genotypes emerge. In this scenario, further studies of infection dispersion by HPV are necessary to ascertain the real impact of the current vaccines, primarily because of the different high-risk HPV types that are found in CC. Hindawi Publishing Corporation 2014 2014-04-03 /pmc/articles/PMC3996882/ /pubmed/24803952 http://dx.doi.org/10.1155/2014/542923 Text en Copyright © 2014 Raúl Peralta et al. https://creativecommons.org/licenses/by/3.0/ This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited. |
spellingShingle | Research Article Peralta, Raúl Vargas-De-León, Cruz Cabrera, Augusto Miramontes, Pedro Dynamics of High-Risk Nonvaccine Human Papillomavirus Types after Actual Vaccination Scheme |
title | Dynamics of High-Risk Nonvaccine Human Papillomavirus Types after Actual Vaccination Scheme |
title_full | Dynamics of High-Risk Nonvaccine Human Papillomavirus Types after Actual Vaccination Scheme |
title_fullStr | Dynamics of High-Risk Nonvaccine Human Papillomavirus Types after Actual Vaccination Scheme |
title_full_unstemmed | Dynamics of High-Risk Nonvaccine Human Papillomavirus Types after Actual Vaccination Scheme |
title_short | Dynamics of High-Risk Nonvaccine Human Papillomavirus Types after Actual Vaccination Scheme |
title_sort | dynamics of high-risk nonvaccine human papillomavirus types after actual vaccination scheme |
topic | Research Article |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3996882/ https://www.ncbi.nlm.nih.gov/pubmed/24803952 http://dx.doi.org/10.1155/2014/542923 |
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