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Human Pluripotent Stem Cell-Derived Cardiomyocytes as Research and Therapeutic Tools

Human pluripotent stem cells (hPSCs), namely, embryonic stem cells (ESCs) and induced pluripotent stem cells (iPSCs), with their ability of indefinite self-renewal and capability to differentiate into cell types derivatives of all three germ layers, represent a powerful research tool in developmenta...

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Detalles Bibliográficos
Autores principales: Acimovic, Ivana, Vilotic, Aleksandra, Pesl, Martin, Lacampagne, Alain, Dvorak, Petr, Rotrekl, Vladimir, Meli, Albano C.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Hindawi Publishing Corporation 2014
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3996932/
https://www.ncbi.nlm.nih.gov/pubmed/24800237
http://dx.doi.org/10.1155/2014/512831
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author Acimovic, Ivana
Vilotic, Aleksandra
Pesl, Martin
Lacampagne, Alain
Dvorak, Petr
Rotrekl, Vladimir
Meli, Albano C.
author_facet Acimovic, Ivana
Vilotic, Aleksandra
Pesl, Martin
Lacampagne, Alain
Dvorak, Petr
Rotrekl, Vladimir
Meli, Albano C.
author_sort Acimovic, Ivana
collection PubMed
description Human pluripotent stem cells (hPSCs), namely, embryonic stem cells (ESCs) and induced pluripotent stem cells (iPSCs), with their ability of indefinite self-renewal and capability to differentiate into cell types derivatives of all three germ layers, represent a powerful research tool in developmental biology, for drug screening, disease modelling, and potentially cell replacement therapy. Efficient differentiation protocols that would result in the cell type of our interest are needed for maximal exploitation of these cells. In the present work, we aim at focusing on the protocols for differentiation of hPSCs into functional cardiomyocytes in vitro as well as achievements in the heart disease modelling and drug testing on the patient-specific iPSC-derived cardiomyocytes (iPSC-CMs).
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spelling pubmed-39969322014-05-05 Human Pluripotent Stem Cell-Derived Cardiomyocytes as Research and Therapeutic Tools Acimovic, Ivana Vilotic, Aleksandra Pesl, Martin Lacampagne, Alain Dvorak, Petr Rotrekl, Vladimir Meli, Albano C. Biomed Res Int Review Article Human pluripotent stem cells (hPSCs), namely, embryonic stem cells (ESCs) and induced pluripotent stem cells (iPSCs), with their ability of indefinite self-renewal and capability to differentiate into cell types derivatives of all three germ layers, represent a powerful research tool in developmental biology, for drug screening, disease modelling, and potentially cell replacement therapy. Efficient differentiation protocols that would result in the cell type of our interest are needed for maximal exploitation of these cells. In the present work, we aim at focusing on the protocols for differentiation of hPSCs into functional cardiomyocytes in vitro as well as achievements in the heart disease modelling and drug testing on the patient-specific iPSC-derived cardiomyocytes (iPSC-CMs). Hindawi Publishing Corporation 2014 2014-04-02 /pmc/articles/PMC3996932/ /pubmed/24800237 http://dx.doi.org/10.1155/2014/512831 Text en Copyright © 2014 Ivana Acimovic et al. https://creativecommons.org/licenses/by/3.0/ This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.
spellingShingle Review Article
Acimovic, Ivana
Vilotic, Aleksandra
Pesl, Martin
Lacampagne, Alain
Dvorak, Petr
Rotrekl, Vladimir
Meli, Albano C.
Human Pluripotent Stem Cell-Derived Cardiomyocytes as Research and Therapeutic Tools
title Human Pluripotent Stem Cell-Derived Cardiomyocytes as Research and Therapeutic Tools
title_full Human Pluripotent Stem Cell-Derived Cardiomyocytes as Research and Therapeutic Tools
title_fullStr Human Pluripotent Stem Cell-Derived Cardiomyocytes as Research and Therapeutic Tools
title_full_unstemmed Human Pluripotent Stem Cell-Derived Cardiomyocytes as Research and Therapeutic Tools
title_short Human Pluripotent Stem Cell-Derived Cardiomyocytes as Research and Therapeutic Tools
title_sort human pluripotent stem cell-derived cardiomyocytes as research and therapeutic tools
topic Review Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3996932/
https://www.ncbi.nlm.nih.gov/pubmed/24800237
http://dx.doi.org/10.1155/2014/512831
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