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Modulation of Endothelial Glycocalyx Structure under Inflammatory Conditions

The glycocalyx of the endothelium is an intravascular compartment that creates a barrier between circulating blood and the vessel wall. The glycocalyx is suggested to play an important role in numerous physiological processes including the regulation of vascular permeability, the prevention of the m...

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Autores principales: Kolářová, Hana, Ambrůzová, Barbora, Švihálková Šindlerová, Lenka, Klinke, Anna, Kubala, Lukáš
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Hindawi Publishing Corporation 2014
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3997148/
https://www.ncbi.nlm.nih.gov/pubmed/24803742
http://dx.doi.org/10.1155/2014/694312
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author Kolářová, Hana
Ambrůzová, Barbora
Švihálková Šindlerová, Lenka
Klinke, Anna
Kubala, Lukáš
author_facet Kolářová, Hana
Ambrůzová, Barbora
Švihálková Šindlerová, Lenka
Klinke, Anna
Kubala, Lukáš
author_sort Kolářová, Hana
collection PubMed
description The glycocalyx of the endothelium is an intravascular compartment that creates a barrier between circulating blood and the vessel wall. The glycocalyx is suggested to play an important role in numerous physiological processes including the regulation of vascular permeability, the prevention of the margination of blood cells to the vessel wall, and the transmission of shear stress. Various theoretical models and experimental approaches provide data about changes to the structure and functions of the glycocalyx under various types of inflammatory conditions. These alterations are suggested to promote inflammatory processes in vessels and contribute to the pathogenesis of number of diseases. In this review we summarize current knowledge about the modulation of the glycocalyx under inflammatory conditions and the consequences for the course of inflammation in vessels. The structure and functions of endothelial glycocalyx are briefly discussed in the context of methodological approaches regarding the determination of endothelial glycocalyx and the uncertainty and challenges involved in glycocalyx structure determination. In addition, the modulation of glycocalyx structure under inflammatory conditions and the possible consequences for pathogenesis of selected diseases and medical conditions (in particular, diabetes, atherosclerosis, ischemia/reperfusion, and sepsis) are summarized. Finally, therapeutic strategies to ameliorate glycocalyx dysfunction suggested by various authors are discussed.
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spelling pubmed-39971482014-05-06 Modulation of Endothelial Glycocalyx Structure under Inflammatory Conditions Kolářová, Hana Ambrůzová, Barbora Švihálková Šindlerová, Lenka Klinke, Anna Kubala, Lukáš Mediators Inflamm Review Article The glycocalyx of the endothelium is an intravascular compartment that creates a barrier between circulating blood and the vessel wall. The glycocalyx is suggested to play an important role in numerous physiological processes including the regulation of vascular permeability, the prevention of the margination of blood cells to the vessel wall, and the transmission of shear stress. Various theoretical models and experimental approaches provide data about changes to the structure and functions of the glycocalyx under various types of inflammatory conditions. These alterations are suggested to promote inflammatory processes in vessels and contribute to the pathogenesis of number of diseases. In this review we summarize current knowledge about the modulation of the glycocalyx under inflammatory conditions and the consequences for the course of inflammation in vessels. The structure and functions of endothelial glycocalyx are briefly discussed in the context of methodological approaches regarding the determination of endothelial glycocalyx and the uncertainty and challenges involved in glycocalyx structure determination. In addition, the modulation of glycocalyx structure under inflammatory conditions and the possible consequences for pathogenesis of selected diseases and medical conditions (in particular, diabetes, atherosclerosis, ischemia/reperfusion, and sepsis) are summarized. Finally, therapeutic strategies to ameliorate glycocalyx dysfunction suggested by various authors are discussed. Hindawi Publishing Corporation 2014 2014-04-03 /pmc/articles/PMC3997148/ /pubmed/24803742 http://dx.doi.org/10.1155/2014/694312 Text en Copyright © 2014 Hana Kolářová et al. https://creativecommons.org/licenses/by/3.0/ This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.
spellingShingle Review Article
Kolářová, Hana
Ambrůzová, Barbora
Švihálková Šindlerová, Lenka
Klinke, Anna
Kubala, Lukáš
Modulation of Endothelial Glycocalyx Structure under Inflammatory Conditions
title Modulation of Endothelial Glycocalyx Structure under Inflammatory Conditions
title_full Modulation of Endothelial Glycocalyx Structure under Inflammatory Conditions
title_fullStr Modulation of Endothelial Glycocalyx Structure under Inflammatory Conditions
title_full_unstemmed Modulation of Endothelial Glycocalyx Structure under Inflammatory Conditions
title_short Modulation of Endothelial Glycocalyx Structure under Inflammatory Conditions
title_sort modulation of endothelial glycocalyx structure under inflammatory conditions
topic Review Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3997148/
https://www.ncbi.nlm.nih.gov/pubmed/24803742
http://dx.doi.org/10.1155/2014/694312
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