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Modulation of Endothelial Glycocalyx Structure under Inflammatory Conditions
The glycocalyx of the endothelium is an intravascular compartment that creates a barrier between circulating blood and the vessel wall. The glycocalyx is suggested to play an important role in numerous physiological processes including the regulation of vascular permeability, the prevention of the m...
Autores principales: | , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Hindawi Publishing Corporation
2014
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3997148/ https://www.ncbi.nlm.nih.gov/pubmed/24803742 http://dx.doi.org/10.1155/2014/694312 |
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author | Kolářová, Hana Ambrůzová, Barbora Švihálková Šindlerová, Lenka Klinke, Anna Kubala, Lukáš |
author_facet | Kolářová, Hana Ambrůzová, Barbora Švihálková Šindlerová, Lenka Klinke, Anna Kubala, Lukáš |
author_sort | Kolářová, Hana |
collection | PubMed |
description | The glycocalyx of the endothelium is an intravascular compartment that creates a barrier between circulating blood and the vessel wall. The glycocalyx is suggested to play an important role in numerous physiological processes including the regulation of vascular permeability, the prevention of the margination of blood cells to the vessel wall, and the transmission of shear stress. Various theoretical models and experimental approaches provide data about changes to the structure and functions of the glycocalyx under various types of inflammatory conditions. These alterations are suggested to promote inflammatory processes in vessels and contribute to the pathogenesis of number of diseases. In this review we summarize current knowledge about the modulation of the glycocalyx under inflammatory conditions and the consequences for the course of inflammation in vessels. The structure and functions of endothelial glycocalyx are briefly discussed in the context of methodological approaches regarding the determination of endothelial glycocalyx and the uncertainty and challenges involved in glycocalyx structure determination. In addition, the modulation of glycocalyx structure under inflammatory conditions and the possible consequences for pathogenesis of selected diseases and medical conditions (in particular, diabetes, atherosclerosis, ischemia/reperfusion, and sepsis) are summarized. Finally, therapeutic strategies to ameliorate glycocalyx dysfunction suggested by various authors are discussed. |
format | Online Article Text |
id | pubmed-3997148 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2014 |
publisher | Hindawi Publishing Corporation |
record_format | MEDLINE/PubMed |
spelling | pubmed-39971482014-05-06 Modulation of Endothelial Glycocalyx Structure under Inflammatory Conditions Kolářová, Hana Ambrůzová, Barbora Švihálková Šindlerová, Lenka Klinke, Anna Kubala, Lukáš Mediators Inflamm Review Article The glycocalyx of the endothelium is an intravascular compartment that creates a barrier between circulating blood and the vessel wall. The glycocalyx is suggested to play an important role in numerous physiological processes including the regulation of vascular permeability, the prevention of the margination of blood cells to the vessel wall, and the transmission of shear stress. Various theoretical models and experimental approaches provide data about changes to the structure and functions of the glycocalyx under various types of inflammatory conditions. These alterations are suggested to promote inflammatory processes in vessels and contribute to the pathogenesis of number of diseases. In this review we summarize current knowledge about the modulation of the glycocalyx under inflammatory conditions and the consequences for the course of inflammation in vessels. The structure and functions of endothelial glycocalyx are briefly discussed in the context of methodological approaches regarding the determination of endothelial glycocalyx and the uncertainty and challenges involved in glycocalyx structure determination. In addition, the modulation of glycocalyx structure under inflammatory conditions and the possible consequences for pathogenesis of selected diseases and medical conditions (in particular, diabetes, atherosclerosis, ischemia/reperfusion, and sepsis) are summarized. Finally, therapeutic strategies to ameliorate glycocalyx dysfunction suggested by various authors are discussed. Hindawi Publishing Corporation 2014 2014-04-03 /pmc/articles/PMC3997148/ /pubmed/24803742 http://dx.doi.org/10.1155/2014/694312 Text en Copyright © 2014 Hana Kolářová et al. https://creativecommons.org/licenses/by/3.0/ This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited. |
spellingShingle | Review Article Kolářová, Hana Ambrůzová, Barbora Švihálková Šindlerová, Lenka Klinke, Anna Kubala, Lukáš Modulation of Endothelial Glycocalyx Structure under Inflammatory Conditions |
title | Modulation of Endothelial Glycocalyx Structure under Inflammatory Conditions |
title_full | Modulation of Endothelial Glycocalyx Structure under Inflammatory Conditions |
title_fullStr | Modulation of Endothelial Glycocalyx Structure under Inflammatory Conditions |
title_full_unstemmed | Modulation of Endothelial Glycocalyx Structure under Inflammatory Conditions |
title_short | Modulation of Endothelial Glycocalyx Structure under Inflammatory Conditions |
title_sort | modulation of endothelial glycocalyx structure under inflammatory conditions |
topic | Review Article |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3997148/ https://www.ncbi.nlm.nih.gov/pubmed/24803742 http://dx.doi.org/10.1155/2014/694312 |
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