Epac and the high affinity rolipram binding conformer of PDE4 modulate neurite outgrowth and myelination using an in vitro spinal cord injury model

BACKGROUND AND PURPOSE: cAMP and pharmacological inhibition of PDE4, which degrades it, are promising therapeutic targets for the treatment of spinal cord injury (SCI). Using our previously described in vitro SCI model, we studied the mechanisms by which cAMP modulators promote neurite outgrowth and...

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Detalles Bibliográficos
Autores principales: Boomkamp, S D, McGrath, M A, Houslay, M D, Barnett, S C
Formato: Online Artículo Texto
Lenguaje:English
Publicado: John Wiley & Sons Ltd 2014
Materias:
Research Papers
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3997278/
https://www.ncbi.nlm.nih.gov/pubmed/24467222
http://dx.doi.org/10.1111/bph.12588

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3997278/
https://www.ncbi.nlm.nih.gov/pubmed/24467222
http://dx.doi.org/10.1111/bph.12588

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