A Protoberberine Derivative HWY336 Selectively Inhibits MKK4 and MKK7 in Mammalian Cells: The Importance of Activation Loop on Selectivity

A protoberberine derivative library was used to search for selective inhibitors against kinases of the mitogen-activated protein kinase (MAPK) cascades in mammalian cells. Among kinases in mammalian MAPK pathways, we identified a compound (HWY336) that selectively inhibits kinase activity of mitogen...

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Detalles Bibliográficos
Autores principales: Kim, Namil, Park, Jeongyeon, Gadhe, Changdev G., Cho, Seung Joo, Oh, Youngjin, Kim, Donghyun, Song, Kiwon
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Public Library of Science 2014
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3997336/
https://www.ncbi.nlm.nih.gov/pubmed/24759688
http://dx.doi.org/10.1371/journal.pone.0091037

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3997336/
https://www.ncbi.nlm.nih.gov/pubmed/24759688
http://dx.doi.org/10.1371/journal.pone.0091037

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