IGF-1R inhibition enhances radiosensitivity and delays double-strand break repair by both non-homologous end-joining and homologous recombination

Inhibition of type 1 insulin-like growth factor receptor (IGF-1R) enhances tumor cell sensitivity to ionizing radiation. It is not clear how this effect is mediated, nor whether this approach can be applied effectively in the clinic. We previously showed that IGF-1R depletion delays repair of radiat...

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Detalles Bibliográficos
Autores principales: Chitnis, Meenali M., Lodhia, Kunal A., Aleksic, Tamara, Gao, Shan, Protheroe, Andrew S., Macaulay, Valentine M.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: 2013
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3997348/
https://www.ncbi.nlm.nih.gov/pubmed/24186206
http://dx.doi.org/10.1038/onc.2013.460

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