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Genetic Polymorphism of Cytochrome P450 4F2, Vitamin E Level and Histological Response in Adults and Children with Nonalcoholic Fatty Liver Disease Who Participated in PIVENS and TONIC Clinical Trials

Vitamin E improved liver histology in children and adults with NAFLD who participated in TONIC and PIVENS clinical trials, but with significant inter-individual variability in its efficacy. Cytochrome P450 4F2 (CYP4F2) is the major enzyme metabolizing Vit E, with two common genetic variants (V433M,...

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Detalles Bibliográficos
Autores principales:	Athinarayanan, Shaminie, Wei, Rongrong, Zhang, Min, Bai, Shaochun, Traber, Maret G., Yates, Katherine, Cummings, Oscar W., Molleston, Jean, Liu, Wanqing, Chalasani, Naga
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Public Library of Science 2014
Materias:	Research Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3997354/ https://www.ncbi.nlm.nih.gov/pubmed/24759732 http://dx.doi.org/10.1371/journal.pone.0095366

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