Specific Activation of K-Ras(G12D) Allele in the Bladder Urothelium Results in Lung Alveolar and Vascular Defects

K-ras is essential for embryogenesis and its mutations are involved in human developmental syndromes and cancer. To determine the consequences of K-ras activation in urothelium, we used uroplakin-II (UPK II) promoter driven Cre recombinase mice and generated mice with mutated Kras(G12D) allele in th...

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Detalles Bibliográficos
Autores principales: Ayala de la Peña, Francisco, Kanasaki, Keizo, Kanasaki, Megumi, Vong, Sylvia, Rovira, Carlota, Kalluri, Raghu
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Public Library of Science 2014
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3997426/
https://www.ncbi.nlm.nih.gov/pubmed/24760005
http://dx.doi.org/10.1371/journal.pone.0095888

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