Sunitinib Suppress Neuroblastoma Growth through Degradation of MYCN and Inhibition of Angiogenesis

Neuroblastoma, a tumor of the peripheral sympathetic nervous system, is the most common and deadly extracranial tumor of childhood. The majority of high-risk neuroblastoma exhibit amplification of the MYCN proto-oncogene and increased neoangiogenesis. Both MYCN protein stabilization and angiogenesis...

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Detalles Bibliográficos
Autores principales: Calero, Raul, Morchon, Esther, Johnsen, John Inge, Serrano, Rosario
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Public Library of Science 2014
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3997473/
https://www.ncbi.nlm.nih.gov/pubmed/24759734
http://dx.doi.org/10.1371/journal.pone.0095628

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3997473/
https://www.ncbi.nlm.nih.gov/pubmed/24759734
http://dx.doi.org/10.1371/journal.pone.0095628

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