Induction of pluripotency by defined factors

The “reversion of cell fate from differentiated states back into totipotent or pluripotent states” has been an interest of many scientists for a long time. With the help of knowledge accumulated by those scientists, we succeeded in converting somatic cells to a pluripotent cell lineage by the forced...

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Detalles Bibliográficos
Autores principales: TANABE, Koji, TAKAHASHI, Kazutoshi, YAMANAKA, Shinya
Formato: Online Artículo Texto
Lenguaje:English
Publicado: The Japan Academy 2014
Materias:
Review
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3997808/
https://www.ncbi.nlm.nih.gov/pubmed/24621955
http://dx.doi.org/10.2183/pjab.90.83
Descripción
Sumario:The “reversion of cell fate from differentiated states back into totipotent or pluripotent states” has been an interest of many scientists for a long time. With the help of knowledge accumulated by those scientists, we succeeded in converting somatic cells to a pluripotent cell lineage by the forced expression of defined factors. These established induced pluripotent stem (iPS) cells have similar features to embryonic stem (ES) cells, including pluripotency and immortality. The iPS cell technology provides unprecedented opportunities for regenerative medicine and drug discovery.

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