Induction of pluripotency by defined factors

The “reversion of cell fate from differentiated states back into totipotent or pluripotent states” has been an interest of many scientists for a long time. With the help of knowledge accumulated by those scientists, we succeeded in converting somatic cells to a pluripotent cell lineage by the forced...

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Detalles Bibliográficos
Autores principales: TANABE, Koji, TAKAHASHI, Kazutoshi, YAMANAKA, Shinya
Formato: Online Artículo Texto
Lenguaje:English
Publicado: The Japan Academy 2014
Materias:
Review
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3997808/
https://www.ncbi.nlm.nih.gov/pubmed/24621955
http://dx.doi.org/10.2183/pjab.90.83
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author TANABE, Koji
TAKAHASHI, Kazutoshi
YAMANAKA, Shinya
author_facet TANABE, Koji
TAKAHASHI, Kazutoshi
YAMANAKA, Shinya
author_sort TANABE, Koji
collection PubMed
description The “reversion of cell fate from differentiated states back into totipotent or pluripotent states” has been an interest of many scientists for a long time. With the help of knowledge accumulated by those scientists, we succeeded in converting somatic cells to a pluripotent cell lineage by the forced expression of defined factors. These established induced pluripotent stem (iPS) cells have similar features to embryonic stem (ES) cells, including pluripotency and immortality. The iPS cell technology provides unprecedented opportunities for regenerative medicine and drug discovery.
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spelling pubmed-39978082014-05-22 Induction of pluripotency by defined factors TANABE, Koji TAKAHASHI, Kazutoshi YAMANAKA, Shinya Proc Jpn Acad Ser B Phys Biol Sci Review The “reversion of cell fate from differentiated states back into totipotent or pluripotent states” has been an interest of many scientists for a long time. With the help of knowledge accumulated by those scientists, we succeeded in converting somatic cells to a pluripotent cell lineage by the forced expression of defined factors. These established induced pluripotent stem (iPS) cells have similar features to embryonic stem (ES) cells, including pluripotency and immortality. The iPS cell technology provides unprecedented opportunities for regenerative medicine and drug discovery. The Japan Academy 2014-03-11 /pmc/articles/PMC3997808/ /pubmed/24621955 http://dx.doi.org/10.2183/pjab.90.83 Text en © 2014 The Japan Academy This is an open access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.
spellingShingle Review
TANABE, Koji
TAKAHASHI, Kazutoshi
YAMANAKA, Shinya
Induction of pluripotency by defined factors
title Induction of pluripotency by defined factors
title_full Induction of pluripotency by defined factors
title_fullStr Induction of pluripotency by defined factors
title_full_unstemmed Induction of pluripotency by defined factors
title_short Induction of pluripotency by defined factors
title_sort induction of pluripotency by defined factors
topic Review
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3997808/
https://www.ncbi.nlm.nih.gov/pubmed/24621955
http://dx.doi.org/10.2183/pjab.90.83
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