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Reporting bias in trials of volume resuscitation with hydroxyethyl starch
The possibility of renal damage by hydroxyethyl starch has become the focus of intensive dispute based on the findings of published large trials. The aim of this narrative review is to analyze outcome reporting bias in the literature on volume resuscitation, focusing on selective outcome reporting i...
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Formato: | Online Artículo Texto |
Lenguaje: | English |
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Springer Vienna
2014
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Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3997826/ https://www.ncbi.nlm.nih.gov/pubmed/24596076 http://dx.doi.org/10.1007/s00508-014-0503-y |
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author | Wiedermann, Christian J. |
author_facet | Wiedermann, Christian J. |
author_sort | Wiedermann, Christian J. |
collection | PubMed |
description | The possibility of renal damage by hydroxyethyl starch has become the focus of intensive dispute based on the findings of published large trials. The aim of this narrative review is to analyze outcome reporting bias in the literature on volume resuscitation, focusing on selective outcome reporting in published randomized and observational trials with “modern” hydroxyethyl starch as therapeutic intervention. Three recent publications claimed to confirm renal safety of hydroxyethyl starch 130/0.4 for indications in severe sepsis, trauma, and critical illness, respectively. Selective outcome reporting was identified in these studies including underreporting of side effects and change of primary study outcomes. In conclusion, selective outcome reporting bias is identified in recent publications of clinical trials on volume resuscitation with HES. |
format | Online Article Text |
id | pubmed-3997826 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2014 |
publisher | Springer Vienna |
record_format | MEDLINE/PubMed |
spelling | pubmed-39978262014-04-25 Reporting bias in trials of volume resuscitation with hydroxyethyl starch Wiedermann, Christian J. Wien Klin Wochenschr Perspective The possibility of renal damage by hydroxyethyl starch has become the focus of intensive dispute based on the findings of published large trials. The aim of this narrative review is to analyze outcome reporting bias in the literature on volume resuscitation, focusing on selective outcome reporting in published randomized and observational trials with “modern” hydroxyethyl starch as therapeutic intervention. Three recent publications claimed to confirm renal safety of hydroxyethyl starch 130/0.4 for indications in severe sepsis, trauma, and critical illness, respectively. Selective outcome reporting was identified in these studies including underreporting of side effects and change of primary study outcomes. In conclusion, selective outcome reporting bias is identified in recent publications of clinical trials on volume resuscitation with HES. Springer Vienna 2014-03-05 2014 /pmc/articles/PMC3997826/ /pubmed/24596076 http://dx.doi.org/10.1007/s00508-014-0503-y Text en © The Author(s) 2014 2014 https://creativecommons.org/licenses/by/4.0/ This article is distributed under the terms of the Creative Commons Attribution License which permits any use, distribution, and reproduction in any medium, provided the original author(s) and the source are credited. |
spellingShingle | Perspective Wiedermann, Christian J. Reporting bias in trials of volume resuscitation with hydroxyethyl starch |
title | Reporting bias in trials of volume resuscitation with hydroxyethyl starch |
title_full | Reporting bias in trials of volume resuscitation with hydroxyethyl starch |
title_fullStr | Reporting bias in trials of volume resuscitation with hydroxyethyl starch |
title_full_unstemmed | Reporting bias in trials of volume resuscitation with hydroxyethyl starch |
title_short | Reporting bias in trials of volume resuscitation with hydroxyethyl starch |
title_sort | reporting bias in trials of volume resuscitation with hydroxyethyl starch |
topic | Perspective |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3997826/ https://www.ncbi.nlm.nih.gov/pubmed/24596076 http://dx.doi.org/10.1007/s00508-014-0503-y |
work_keys_str_mv | AT wiedermannchristianj reportingbiasintrialsofvolumeresuscitationwithhydroxyethylstarch |