Cargando…

Reporting bias in trials of volume resuscitation with hydroxyethyl starch

The possibility of renal damage by hydroxyethyl starch has become the focus of intensive dispute based on the findings of published large trials. The aim of this narrative review is to analyze outcome reporting bias in the literature on volume resuscitation, focusing on selective outcome reporting i...

Descripción completa

Detalles Bibliográficos
Autor principal: Wiedermann, Christian J.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Springer Vienna 2014
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3997826/
https://www.ncbi.nlm.nih.gov/pubmed/24596076
http://dx.doi.org/10.1007/s00508-014-0503-y
_version_ 1782313239568187392
author Wiedermann, Christian J.
author_facet Wiedermann, Christian J.
author_sort Wiedermann, Christian J.
collection PubMed
description The possibility of renal damage by hydroxyethyl starch has become the focus of intensive dispute based on the findings of published large trials. The aim of this narrative review is to analyze outcome reporting bias in the literature on volume resuscitation, focusing on selective outcome reporting in published randomized and observational trials with “modern” hydroxyethyl starch as therapeutic intervention. Three recent publications claimed to confirm renal safety of hydroxyethyl starch 130/0.4 for indications in severe sepsis, trauma, and critical illness, respectively. Selective outcome reporting was identified in these studies including underreporting of side effects and change of primary study outcomes. In conclusion, selective outcome reporting bias is identified in recent publications of clinical trials on volume resuscitation with HES.
format Online
Article
Text
id pubmed-3997826
institution National Center for Biotechnology Information
language English
publishDate 2014
publisher Springer Vienna
record_format MEDLINE/PubMed
spelling pubmed-39978262014-04-25 Reporting bias in trials of volume resuscitation with hydroxyethyl starch Wiedermann, Christian J. Wien Klin Wochenschr Perspective The possibility of renal damage by hydroxyethyl starch has become the focus of intensive dispute based on the findings of published large trials. The aim of this narrative review is to analyze outcome reporting bias in the literature on volume resuscitation, focusing on selective outcome reporting in published randomized and observational trials with “modern” hydroxyethyl starch as therapeutic intervention. Three recent publications claimed to confirm renal safety of hydroxyethyl starch 130/0.4 for indications in severe sepsis, trauma, and critical illness, respectively. Selective outcome reporting was identified in these studies including underreporting of side effects and change of primary study outcomes. In conclusion, selective outcome reporting bias is identified in recent publications of clinical trials on volume resuscitation with HES. Springer Vienna 2014-03-05 2014 /pmc/articles/PMC3997826/ /pubmed/24596076 http://dx.doi.org/10.1007/s00508-014-0503-y Text en © The Author(s) 2014 2014 https://creativecommons.org/licenses/by/4.0/ This article is distributed under the terms of the Creative Commons Attribution License which permits any use, distribution, and reproduction in any medium, provided the original author(s) and the source are credited.
spellingShingle Perspective
Wiedermann, Christian J.
Reporting bias in trials of volume resuscitation with hydroxyethyl starch
title Reporting bias in trials of volume resuscitation with hydroxyethyl starch
title_full Reporting bias in trials of volume resuscitation with hydroxyethyl starch
title_fullStr Reporting bias in trials of volume resuscitation with hydroxyethyl starch
title_full_unstemmed Reporting bias in trials of volume resuscitation with hydroxyethyl starch
title_short Reporting bias in trials of volume resuscitation with hydroxyethyl starch
title_sort reporting bias in trials of volume resuscitation with hydroxyethyl starch
topic Perspective
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3997826/
https://www.ncbi.nlm.nih.gov/pubmed/24596076
http://dx.doi.org/10.1007/s00508-014-0503-y
work_keys_str_mv AT wiedermannchristianj reportingbiasintrialsofvolumeresuscitationwithhydroxyethylstarch