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Tumour-associated endothelial-FAK correlated with molecular sub-type and prognostic factors in invasive breast cancer
BACKGROUND: Breast cancer is a heterogeneous disease that can be classified into one of 4 main molecular sub-types: luminal A, luminal B, Her2 over-expressing and basal-like (BL). These tumour sub-types require different treatments and have different risks of disease progression. BL cancers can be c...
Autores principales: | , , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
BioMed Central
2014
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3997837/ https://www.ncbi.nlm.nih.gov/pubmed/24693876 http://dx.doi.org/10.1186/1471-2407-14-237 |
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author | Alexopoulou, Annika N Ho-Yen, Colan M Papalazarou, Vassilis Elia, George Jones, J Louise Hodivala-Dilke, Kairbaan |
author_facet | Alexopoulou, Annika N Ho-Yen, Colan M Papalazarou, Vassilis Elia, George Jones, J Louise Hodivala-Dilke, Kairbaan |
author_sort | Alexopoulou, Annika N |
collection | PubMed |
description | BACKGROUND: Breast cancer is a heterogeneous disease that can be classified into one of 4 main molecular sub-types: luminal A, luminal B, Her2 over-expressing and basal-like (BL). These tumour sub-types require different treatments and have different risks of disease progression. BL cancers can be considered a sub-group of Triple negative (TN) cancers since they lack estrogen (ER), progesterone (PR) and Her2 expression. No targeted treatment currently exists for TN/BL cancers. Thus it is important to identify potential therapeutic targets and describe their relationship with established prognostic factors. Focal adhesion kinase (FAK) is upregulated in several human cancers and also plays a functional role in tumour angiogenesis. However, the association between breast cancer sub-types and tumour endothelial-FAK expression is unknown. METHODS: Using immunofluorescence, we quantified FAK expression in tumour endothelial and tumour cell compartments in 149 invasive breast carcinomas and correlated expression with clinical, pathological and molecular parameters. RESULTS: Low endothelial-FAK expression was independently associated with luminal A tumours at univariate (p < 0.001) and multivariate (p = 0.001) analysis. There was a positive correlation between FAK expression in the vascular and tumour cell compartments (Spearman’s correlation co-efficient = 0.394, p < 0.001). Additionally, endothelial and tumour cell FAK expression were significantly increased in TN tumours (p = 0.043 and p = 0.033 respectively), in tumours with negative ER and PR status, and in high grade tumours at univariate analysis. CONCLUSION: Our findings establish a relationship between endothelial-FAK expression levels and the molecular sub-type of invasive breast cancer, and suggest that endothelial-FAK expression is potentially more clinically relevant than tumour cell FAK expression in breast cancer. |
format | Online Article Text |
id | pubmed-3997837 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2014 |
publisher | BioMed Central |
record_format | MEDLINE/PubMed |
spelling | pubmed-39978372014-04-25 Tumour-associated endothelial-FAK correlated with molecular sub-type and prognostic factors in invasive breast cancer Alexopoulou, Annika N Ho-Yen, Colan M Papalazarou, Vassilis Elia, George Jones, J Louise Hodivala-Dilke, Kairbaan BMC Cancer Research Article BACKGROUND: Breast cancer is a heterogeneous disease that can be classified into one of 4 main molecular sub-types: luminal A, luminal B, Her2 over-expressing and basal-like (BL). These tumour sub-types require different treatments and have different risks of disease progression. BL cancers can be considered a sub-group of Triple negative (TN) cancers since they lack estrogen (ER), progesterone (PR) and Her2 expression. No targeted treatment currently exists for TN/BL cancers. Thus it is important to identify potential therapeutic targets and describe their relationship with established prognostic factors. Focal adhesion kinase (FAK) is upregulated in several human cancers and also plays a functional role in tumour angiogenesis. However, the association between breast cancer sub-types and tumour endothelial-FAK expression is unknown. METHODS: Using immunofluorescence, we quantified FAK expression in tumour endothelial and tumour cell compartments in 149 invasive breast carcinomas and correlated expression with clinical, pathological and molecular parameters. RESULTS: Low endothelial-FAK expression was independently associated with luminal A tumours at univariate (p < 0.001) and multivariate (p = 0.001) analysis. There was a positive correlation between FAK expression in the vascular and tumour cell compartments (Spearman’s correlation co-efficient = 0.394, p < 0.001). Additionally, endothelial and tumour cell FAK expression were significantly increased in TN tumours (p = 0.043 and p = 0.033 respectively), in tumours with negative ER and PR status, and in high grade tumours at univariate analysis. CONCLUSION: Our findings establish a relationship between endothelial-FAK expression levels and the molecular sub-type of invasive breast cancer, and suggest that endothelial-FAK expression is potentially more clinically relevant than tumour cell FAK expression in breast cancer. BioMed Central 2014-04-02 /pmc/articles/PMC3997837/ /pubmed/24693876 http://dx.doi.org/10.1186/1471-2407-14-237 Text en Copyright © 2014 Alexopoulou et al.; licensee BioMed Central Ltd. http://creativecommons.org/licenses/by/2.0 This is an Open Access article distributed under the terms of the Creative Commons Attribution License (http://creativecommons.org/licenses/by/2.0), which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly credited. |
spellingShingle | Research Article Alexopoulou, Annika N Ho-Yen, Colan M Papalazarou, Vassilis Elia, George Jones, J Louise Hodivala-Dilke, Kairbaan Tumour-associated endothelial-FAK correlated with molecular sub-type and prognostic factors in invasive breast cancer |
title | Tumour-associated endothelial-FAK correlated with molecular sub-type and prognostic factors in invasive breast cancer |
title_full | Tumour-associated endothelial-FAK correlated with molecular sub-type and prognostic factors in invasive breast cancer |
title_fullStr | Tumour-associated endothelial-FAK correlated with molecular sub-type and prognostic factors in invasive breast cancer |
title_full_unstemmed | Tumour-associated endothelial-FAK correlated with molecular sub-type and prognostic factors in invasive breast cancer |
title_short | Tumour-associated endothelial-FAK correlated with molecular sub-type and prognostic factors in invasive breast cancer |
title_sort | tumour-associated endothelial-fak correlated with molecular sub-type and prognostic factors in invasive breast cancer |
topic | Research Article |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3997837/ https://www.ncbi.nlm.nih.gov/pubmed/24693876 http://dx.doi.org/10.1186/1471-2407-14-237 |
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