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Cuneus and fusiform cortices thickness is reduced in trigeminal neuralgia

BACKGROUND: Chronic pain disorders are presumed to induce changes in brain grey and white matters. Few studies have focused CNS alterations in trigeminal neuralgia (TN). METHODS: The aim of this study was to explore changes in white matter microstructure in TN subjects using diffusion tensor images...

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Autores principales: Parise, Maud, Kubo, Tadeu Takao Almodovar, Doring, Thomas Martin, Tukamoto, Gustavo, Vincent, Maurice, Gasparetto, Emerson Leandro
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Springer 2014
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3997919/
https://www.ncbi.nlm.nih.gov/pubmed/24661349
http://dx.doi.org/10.1186/1129-2377-15-17
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author Parise, Maud
Kubo, Tadeu Takao Almodovar
Doring, Thomas Martin
Tukamoto, Gustavo
Vincent, Maurice
Gasparetto, Emerson Leandro
author_facet Parise, Maud
Kubo, Tadeu Takao Almodovar
Doring, Thomas Martin
Tukamoto, Gustavo
Vincent, Maurice
Gasparetto, Emerson Leandro
author_sort Parise, Maud
collection PubMed
description BACKGROUND: Chronic pain disorders are presumed to induce changes in brain grey and white matters. Few studies have focused CNS alterations in trigeminal neuralgia (TN). METHODS: The aim of this study was to explore changes in white matter microstructure in TN subjects using diffusion tensor images (DTI) with tract-based spatial statistics (TBSS); and cortical thickness changes with surface based morphometry. Twenty-four patients with classical TN (37-67 y-o) and 24 healthy controls, matched for age and sex, were included in the study. RESULTS: Comparing patients with controls, no diffusivity abnormalities of brain white matter were detected. However, a significant reduction in cortical thickness was observed at the left cuneus and left fusiform cortex in the patients group. The thickness of the fusiform cortex correlated negatively with the carbamazepine dose (p = 0.023). CONCLUSIONS: Since the cuneus and the fusiform gyrus have been related to the multisensory integration area and cognitive processing, as well as the retrieval of shock perception conveyed by Aδ fibers, our results support the role of these areas in TN pathogenesis. Whether such changes occurs as an epiphenomenon secondary to daily stimulation or represent a structural predisposition to TN in the light of peripheral vascular compression is a matter of future studies.
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spelling pubmed-39979192014-05-01 Cuneus and fusiform cortices thickness is reduced in trigeminal neuralgia Parise, Maud Kubo, Tadeu Takao Almodovar Doring, Thomas Martin Tukamoto, Gustavo Vincent, Maurice Gasparetto, Emerson Leandro J Headache Pain Research Article BACKGROUND: Chronic pain disorders are presumed to induce changes in brain grey and white matters. Few studies have focused CNS alterations in trigeminal neuralgia (TN). METHODS: The aim of this study was to explore changes in white matter microstructure in TN subjects using diffusion tensor images (DTI) with tract-based spatial statistics (TBSS); and cortical thickness changes with surface based morphometry. Twenty-four patients with classical TN (37-67 y-o) and 24 healthy controls, matched for age and sex, were included in the study. RESULTS: Comparing patients with controls, no diffusivity abnormalities of brain white matter were detected. However, a significant reduction in cortical thickness was observed at the left cuneus and left fusiform cortex in the patients group. The thickness of the fusiform cortex correlated negatively with the carbamazepine dose (p = 0.023). CONCLUSIONS: Since the cuneus and the fusiform gyrus have been related to the multisensory integration area and cognitive processing, as well as the retrieval of shock perception conveyed by Aδ fibers, our results support the role of these areas in TN pathogenesis. Whether such changes occurs as an epiphenomenon secondary to daily stimulation or represent a structural predisposition to TN in the light of peripheral vascular compression is a matter of future studies. Springer 2014 2014-03-24 /pmc/articles/PMC3997919/ /pubmed/24661349 http://dx.doi.org/10.1186/1129-2377-15-17 Text en Copyright © 2014 Parise et al.; licensee Springer. http://creativecommons.org/licenses/by/4.0 This is an Open Access article distributed under the terms of the Creative Commons Attribution License (http://creativecommons.org/licenses/by/4.0), which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly credited.
spellingShingle Research Article
Parise, Maud
Kubo, Tadeu Takao Almodovar
Doring, Thomas Martin
Tukamoto, Gustavo
Vincent, Maurice
Gasparetto, Emerson Leandro
Cuneus and fusiform cortices thickness is reduced in trigeminal neuralgia
title Cuneus and fusiform cortices thickness is reduced in trigeminal neuralgia
title_full Cuneus and fusiform cortices thickness is reduced in trigeminal neuralgia
title_fullStr Cuneus and fusiform cortices thickness is reduced in trigeminal neuralgia
title_full_unstemmed Cuneus and fusiform cortices thickness is reduced in trigeminal neuralgia
title_short Cuneus and fusiform cortices thickness is reduced in trigeminal neuralgia
title_sort cuneus and fusiform cortices thickness is reduced in trigeminal neuralgia
topic Research Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3997919/
https://www.ncbi.nlm.nih.gov/pubmed/24661349
http://dx.doi.org/10.1186/1129-2377-15-17
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