Cargando…

p16(INK4A) and p14(ARF) Gene Promoter Hypermethylation as Prognostic Biomarker in Oral and Oropharyngeal Squamous Cell Carcinoma: A Review

Head and neck squamous cell carcinoma is a heterogeneous group of tumors with each subtype having a distinct histopathological and molecular profile. Most tumors share, to some extent, the same multistep carcinogenic pathways, which include a wide variety of genetic and epigenetic changes. Epigeneti...

Descripción completa

Detalles Bibliográficos
Autores principales:	Al-Kaabi, A., van Bockel, L. W., Pothen, A. J., Willems, S. M.
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Hindawi Publishing Corporation 2014
Materias:	Review Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3997957/ https://www.ncbi.nlm.nih.gov/pubmed/24803719 http://dx.doi.org/10.1155/2014/260549

Ejemplares similares

Epigenetic changes in the CDKN2A locus are associated with differential expression of P16INK4A and P14ARF in HPV-positive oropharyngeal squamous cell carcinoma
por: Schlecht, Nicolas F, et al.
Publicado: (2015)

The Senescence Markers p16INK4A, p14ARF/p19ARF, and p21 in Organ Development and Homeostasis
por: Wagner, Kay-Dietrich, et al.
Publicado: (2022)

Methylation status of p14ARF and p16INK4a as detected in pancreatic secretions
por: Klump, B, et al.
Publicado: (2003)

Aberrations of the p14(ARF) and p16(INK4a) Genes in Renal Cell Carcinomas
por: Kawada, Yoichi, et al.
Publicado: (2001)

p16(INK4a )hypermethylation and p53, p16 and MDM2 protein expression in Esophageal Squamous Cell Carcinoma
por: Taghavi, Noushin, et al.
Publicado: (2010)

Effect of Iodine Intake on p14ARF and p16INK4a Expression in Thyroid Papillary Carcinoma in Rats
por: Sun, Ruimei, et al.
Publicado: (2015)

Ratio of Expression of p16(INK4a) to p14(ARF) Correlates with the Progression of Non‐small Cell Lung Cancer
por: Moriyama, Satoru, et al.
Publicado: (2002)

The status of CDKN2A alpha (p16(INK4A)) and beta (p14(ARF)) transcripts in thyroid tumour progression
por: Ferru, A, et al.
Publicado: (2006)

HPV-positive oropharyngeal squamous cell carcinoma is associated with TIMP3 and CADM1 promoter hypermethylation
por: van Kempen, Pauline M W, et al.
Publicado: (2014)

Clinical significance of p16(INK4A) and p14(ARF) promoter methylation in renal cell carcinoma: a meta-analysis
por: Ren, Yu, et al.
Publicado: (2017)

Frequency of P16INK4a and P14ARF Genes Methylation and Its Impact on Bladder Cancer Cases in North Indian Population
por: Ali Hosseini, Seyed, et al.
Publicado: (2010)

Evaluation of p16 expression in oral and oropharyngeal squamous cell carcinoma
por: Saxena, Pallavi, et al.
Publicado: (2022)

The effects of fucodian on senescence are controlled by the p16(INK4a)-pRb and p14(Arf)-p53 pathways in hepatocellular carcinoma and hepatic cell lines
por: MIN, EUN-YOUNG, et al.
Publicado: (2014)

Aberrant Expression of pRb, p16, p14ARF, MDM2, p21 and p53 in Squamous Cell Carcinomas of Lung
por: Xue, Qi, et al.
Publicado: (2001)

Chimeras of p14ARF and p16: Functional Hybrids with the Ability to Arrest Growth
por: Williams, Richard T., et al.
Publicado: (2014)

Hypermethylation of p16(INK4a) in Korean Non-small Cell Lung Cancer Patients
por: Hong, Young-Seoub, et al.
Publicado: (2007)

Biological significance of promoter hypermethylation of p14/ARF gene: Relationships to p53 mutational status in Tunisian population with colorectal carcinoma
por: Chaar, Ines, et al.
Publicado: (2013)

Methylation and Immunoexpression of p16(INK4a) Tumor Suppressor Gene in Primary Breast Cancer Tissue and Their Quantitative p16(INK4a) Hypermethylation in Plasma by Real-Time PCR
por: Lee, Jae Jun, et al.
Publicado: (2012)

Associations of P16(INK4a) promoter hypermethylation with squamous intra-epithelial lesion, cervical cancer and their clinicopathological features: a meta-analysis
por: Han, Ya-di, et al.
Publicado: (2016)

Individuals with presumably hereditary uveal melanoma do not harbour germline mutations in the coding regions of either the P16(INK4A), P14(ARF) or cdk4 genes
por: Soufir, N, et al.
Publicado: (2000)

PD-L1 expression is associated with p16(INK4A) expression in non-oropharyngeal head and neck squamous cell carcinoma
por: Chen, San-Chi, et al.
Publicado: (2018)

Immortalization of mouse myogenic cells can occur without loss of p16(INK4a), p19(ARF), or p53 and is accelerated by inactivation of Bax
por: Nowak, Jonathan A, et al.
Publicado: (2004)

Role of p14(ARF) and p15(INK4B) promoter methylation in patients with lung cancer: a systematic meta-analysis
por: Yang, Xinmei, et al.
Publicado: (2016)

Prognostic utility of HPV specific testing in addition to p16 immunohistochemistry in oropharyngeal squamous cell carcinoma
por: Sathasivam, H P, et al.
Publicado: (2018)

p16 (INK4a) has clinicopathological and prognostic impact on oropharynx and larynx squamous cell carcinoma
por: Silva, S.D., et al.
Publicado: (2012)

Evaluation of p16(INK4α) Hypermethylation from Liquid-based Pap Test Samples in Vietnamese Population
por: TRUONG, Phuong Kim, et al.
Publicado: (2017)

Treatment failure patterns are similar between p16− and p16+ oropharyngeal squamous cell carcinomas
por: Hamill, Chelsea S., et al.
Publicado: (2022)

The Prognostic Value of p16 Hypermethylation in Cancer: A Meta-Analysis
por: Xing, Xiang-Bin, et al.
Publicado: (2013)

P14(ARF): The Absence that Makes the Difference
por: Cilluffo, Danilo, et al.
Publicado: (2020)

Induction Chemotherapy for p16 Positive Oropharyngeal Squamous Cell Carcinoma
por: Saito, Yuki, et al.
Publicado: (2016)

Molecular Analysis of Tumor Suppressor Genes, Rb, p53,pl6INK4A, pl5INK4B and p14ARF in Natural Killer Cell Neoplasms
por: Sakajiri, Sakura, et al.
Publicado: (2001)

Potential association of the prognostic index and survival in patients with p16-positive oropharyngeal squamous cell carcinoma
por: Brkic, Faris F., et al.
Publicado: (2021)

Promoter Hypermethylation of Tumor-Suppressor Genes p16(INK4a), RASSF1A, TIMP3, and PCQAP/MED15 in Salivary DNA as a Quadruple Biomarker Panel for Early Detection of Oral and Oropharyngeal Cancers
por: Liyanage, Chamikara, et al.
Publicado: (2019)

Margin Sampling and Survival Outcomes in Oral Cavity and p16-Positive Oropharyngeal Squamous Cell Carcinoma
por: MacKay, Colin, et al.
Publicado: (2022)

Progressive silencing of p14ARF in oesophageal adenocarcinoma
por: Huang, Yinghui, et al.
Publicado: (2009)

Acquired hypermethylation of the P16(INK4A) promoter in abdominal paraganglioma: relation to adverse tumor phenotype and predisposing mutation
por: Kiss, Nimrod B, et al.
Publicado: (2013)

Hypermethylation status of DAPK, MGMT and RUNX3 in HPV negative oral and oropharyngeal squamous cell carcinoma
por: dos Reis, Raquel Silva, et al.
Publicado: (2020)

Expression of p16(INK4a) in oropharyngeal squamous cell carcinoma from a tertiary cancer centre of South India: A preliminary study
por: Pandiar, Deepak, et al.
Publicado: (2021)

Immunohistochemical Evaluation of p16 and p53 in Oral and Oropharyngeal Squamous Cell Carcinoma with Special Regard to Human Papillomavirus Status
por: Ghosh, Urvashi, et al.
Publicado: (2022)

p53 and p16(Ink4a)/p19(Arf) Loss Promotes Different Pancreatic Tumor Types from PyMT-Expressing Progenitor Cells()()
por: Azzopardi, Stephanie, et al.
Publicado: (2016)

Cannot write session to /tmp/vufind_sessions/sess_t8qb3au15iac08nsjpj98muls5