Evaluation of Novel Design Strategies for Developing Zinc Finger Nucleases Tools for Treating Human Diseases

Zinc finger nucleases (ZFNs) are associated with cell death and apoptosis by binding at countless undesired locations. This cytotoxicity is associated with the binding ability of engineered zinc finger domains to bind dissimilar DNA sequences with high affinity. In general, binding preferences of tr...

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Detalles Bibliográficos
Autores principales: Bach, Christian, Sherman, William, Pallis, Jani, Patra, Prabir, Bajwa, Hassan
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Hindawi Publishing Corporation 2014
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3997970/
https://www.ncbi.nlm.nih.gov/pubmed/24808958
http://dx.doi.org/10.1155/2014/970595

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