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Expressions of ABCG2, CD133, and Podoplanin in Salivary Adenoid Cystic Carcinoma
Adenoid cystic carcinoma (ACC) is one of the most common salivary gland malignant tumors with a high risk of recurrence and metastasis. Current studies on cancer stem cells (CSCs) have verified that CSCs are the driving force behind tumor initiation and progression, suggesting that new cancer therap...
Autores principales: | , , , , , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Hindawi Publishing Corporation
2014
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3998002/ https://www.ncbi.nlm.nih.gov/pubmed/24804195 http://dx.doi.org/10.1155/2014/132349 |
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author | Li, Wuwei Tamamura, Ryo Wang, Bo Liu, Qigui Liu, Han Liu, Tingjiao Katase, Naoki Xiao, Jing Nagatsuka, Hitoshi |
author_facet | Li, Wuwei Tamamura, Ryo Wang, Bo Liu, Qigui Liu, Han Liu, Tingjiao Katase, Naoki Xiao, Jing Nagatsuka, Hitoshi |
author_sort | Li, Wuwei |
collection | PubMed |
description | Adenoid cystic carcinoma (ACC) is one of the most common salivary gland malignant tumors with a high risk of recurrence and metastasis. Current studies on cancer stem cells (CSCs) have verified that CSCs are the driving force behind tumor initiation and progression, suggesting that new cancer therapies may be established by effectively targeting and killing the CSCs. The primary goal of this study is to investigate the expression patterns of ABCG2, CD133, and podoplanin in ACC of minor salivary glands by immunohistochemistry analysis. We found that ABCG2 was weakly expressed in normal looking salivary gland tissues. A significant upregulation of ABCG2 expression in ACC was observed with a similar expression pattern of Ki-67. CD133 was detected in apical membrane of epithelial cells and podoplanin was expressed positively in myoepithelial cells of both normal looking tissue and ACC. However, no significant difference was found of the expression pattern of CD133 and podoplanin between normal looking tissues and ACC. Our observations suggest that CSCs may exist in quiescent cells with ABCG2 positive staining, which are surrounded by cells with positive expression of ABCG2 and Ki-67 in ACC, and costaining with ABCG2 and Ki-67 may help predict the location of CSCs. |
format | Online Article Text |
id | pubmed-3998002 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2014 |
publisher | Hindawi Publishing Corporation |
record_format | MEDLINE/PubMed |
spelling | pubmed-39980022014-05-06 Expressions of ABCG2, CD133, and Podoplanin in Salivary Adenoid Cystic Carcinoma Li, Wuwei Tamamura, Ryo Wang, Bo Liu, Qigui Liu, Han Liu, Tingjiao Katase, Naoki Xiao, Jing Nagatsuka, Hitoshi Biomed Res Int Research Article Adenoid cystic carcinoma (ACC) is one of the most common salivary gland malignant tumors with a high risk of recurrence and metastasis. Current studies on cancer stem cells (CSCs) have verified that CSCs are the driving force behind tumor initiation and progression, suggesting that new cancer therapies may be established by effectively targeting and killing the CSCs. The primary goal of this study is to investigate the expression patterns of ABCG2, CD133, and podoplanin in ACC of minor salivary glands by immunohistochemistry analysis. We found that ABCG2 was weakly expressed in normal looking salivary gland tissues. A significant upregulation of ABCG2 expression in ACC was observed with a similar expression pattern of Ki-67. CD133 was detected in apical membrane of epithelial cells and podoplanin was expressed positively in myoepithelial cells of both normal looking tissue and ACC. However, no significant difference was found of the expression pattern of CD133 and podoplanin between normal looking tissues and ACC. Our observations suggest that CSCs may exist in quiescent cells with ABCG2 positive staining, which are surrounded by cells with positive expression of ABCG2 and Ki-67 in ACC, and costaining with ABCG2 and Ki-67 may help predict the location of CSCs. Hindawi Publishing Corporation 2014 2014-04-06 /pmc/articles/PMC3998002/ /pubmed/24804195 http://dx.doi.org/10.1155/2014/132349 Text en Copyright © 2014 Wuwei Li et al. https://creativecommons.org/licenses/by/3.0/ This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited. |
spellingShingle | Research Article Li, Wuwei Tamamura, Ryo Wang, Bo Liu, Qigui Liu, Han Liu, Tingjiao Katase, Naoki Xiao, Jing Nagatsuka, Hitoshi Expressions of ABCG2, CD133, and Podoplanin in Salivary Adenoid Cystic Carcinoma |
title | Expressions of ABCG2, CD133, and Podoplanin in Salivary Adenoid Cystic Carcinoma |
title_full | Expressions of ABCG2, CD133, and Podoplanin in Salivary Adenoid Cystic Carcinoma |
title_fullStr | Expressions of ABCG2, CD133, and Podoplanin in Salivary Adenoid Cystic Carcinoma |
title_full_unstemmed | Expressions of ABCG2, CD133, and Podoplanin in Salivary Adenoid Cystic Carcinoma |
title_short | Expressions of ABCG2, CD133, and Podoplanin in Salivary Adenoid Cystic Carcinoma |
title_sort | expressions of abcg2, cd133, and podoplanin in salivary adenoid cystic carcinoma |
topic | Research Article |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3998002/ https://www.ncbi.nlm.nih.gov/pubmed/24804195 http://dx.doi.org/10.1155/2014/132349 |
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