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Expressions of ABCG2, CD133, and Podoplanin in Salivary Adenoid Cystic Carcinoma

Adenoid cystic carcinoma (ACC) is one of the most common salivary gland malignant tumors with a high risk of recurrence and metastasis. Current studies on cancer stem cells (CSCs) have verified that CSCs are the driving force behind tumor initiation and progression, suggesting that new cancer therap...

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Autores principales: Li, Wuwei, Tamamura, Ryo, Wang, Bo, Liu, Qigui, Liu, Han, Liu, Tingjiao, Katase, Naoki, Xiao, Jing, Nagatsuka, Hitoshi
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Hindawi Publishing Corporation 2014
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3998002/
https://www.ncbi.nlm.nih.gov/pubmed/24804195
http://dx.doi.org/10.1155/2014/132349
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author Li, Wuwei
Tamamura, Ryo
Wang, Bo
Liu, Qigui
Liu, Han
Liu, Tingjiao
Katase, Naoki
Xiao, Jing
Nagatsuka, Hitoshi
author_facet Li, Wuwei
Tamamura, Ryo
Wang, Bo
Liu, Qigui
Liu, Han
Liu, Tingjiao
Katase, Naoki
Xiao, Jing
Nagatsuka, Hitoshi
author_sort Li, Wuwei
collection PubMed
description Adenoid cystic carcinoma (ACC) is one of the most common salivary gland malignant tumors with a high risk of recurrence and metastasis. Current studies on cancer stem cells (CSCs) have verified that CSCs are the driving force behind tumor initiation and progression, suggesting that new cancer therapies may be established by effectively targeting and killing the CSCs. The primary goal of this study is to investigate the expression patterns of ABCG2, CD133, and podoplanin in ACC of minor salivary glands by immunohistochemistry analysis. We found that ABCG2 was weakly expressed in normal looking salivary gland tissues. A significant upregulation of ABCG2 expression in ACC was observed with a similar expression pattern of Ki-67. CD133 was detected in apical membrane of epithelial cells and podoplanin was expressed positively in myoepithelial cells of both normal looking tissue and ACC. However, no significant difference was found of the expression pattern of CD133 and podoplanin between normal looking tissues and ACC. Our observations suggest that CSCs may exist in quiescent cells with ABCG2 positive staining, which are surrounded by cells with positive expression of ABCG2 and Ki-67 in ACC, and costaining with ABCG2 and Ki-67 may help predict the location of CSCs.
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spelling pubmed-39980022014-05-06 Expressions of ABCG2, CD133, and Podoplanin in Salivary Adenoid Cystic Carcinoma Li, Wuwei Tamamura, Ryo Wang, Bo Liu, Qigui Liu, Han Liu, Tingjiao Katase, Naoki Xiao, Jing Nagatsuka, Hitoshi Biomed Res Int Research Article Adenoid cystic carcinoma (ACC) is one of the most common salivary gland malignant tumors with a high risk of recurrence and metastasis. Current studies on cancer stem cells (CSCs) have verified that CSCs are the driving force behind tumor initiation and progression, suggesting that new cancer therapies may be established by effectively targeting and killing the CSCs. The primary goal of this study is to investigate the expression patterns of ABCG2, CD133, and podoplanin in ACC of minor salivary glands by immunohistochemistry analysis. We found that ABCG2 was weakly expressed in normal looking salivary gland tissues. A significant upregulation of ABCG2 expression in ACC was observed with a similar expression pattern of Ki-67. CD133 was detected in apical membrane of epithelial cells and podoplanin was expressed positively in myoepithelial cells of both normal looking tissue and ACC. However, no significant difference was found of the expression pattern of CD133 and podoplanin between normal looking tissues and ACC. Our observations suggest that CSCs may exist in quiescent cells with ABCG2 positive staining, which are surrounded by cells with positive expression of ABCG2 and Ki-67 in ACC, and costaining with ABCG2 and Ki-67 may help predict the location of CSCs. Hindawi Publishing Corporation 2014 2014-04-06 /pmc/articles/PMC3998002/ /pubmed/24804195 http://dx.doi.org/10.1155/2014/132349 Text en Copyright © 2014 Wuwei Li et al. https://creativecommons.org/licenses/by/3.0/ This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.
spellingShingle Research Article
Li, Wuwei
Tamamura, Ryo
Wang, Bo
Liu, Qigui
Liu, Han
Liu, Tingjiao
Katase, Naoki
Xiao, Jing
Nagatsuka, Hitoshi
Expressions of ABCG2, CD133, and Podoplanin in Salivary Adenoid Cystic Carcinoma
title Expressions of ABCG2, CD133, and Podoplanin in Salivary Adenoid Cystic Carcinoma
title_full Expressions of ABCG2, CD133, and Podoplanin in Salivary Adenoid Cystic Carcinoma
title_fullStr Expressions of ABCG2, CD133, and Podoplanin in Salivary Adenoid Cystic Carcinoma
title_full_unstemmed Expressions of ABCG2, CD133, and Podoplanin in Salivary Adenoid Cystic Carcinoma
title_short Expressions of ABCG2, CD133, and Podoplanin in Salivary Adenoid Cystic Carcinoma
title_sort expressions of abcg2, cd133, and podoplanin in salivary adenoid cystic carcinoma
topic Research Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3998002/
https://www.ncbi.nlm.nih.gov/pubmed/24804195
http://dx.doi.org/10.1155/2014/132349
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