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Methyl 3′-(2,5-dimethylbenzyl)-1′-methyl-2-oxo-4′-phenylspiro[indoline-3,2′-pyrrolidine]-3′-carboxylate chloroform monosolvate
In the title solvate, C(29)H(30)N(2)O(3)·CHCl(3), the dihedral angle between the indole ring system (r.m.s. deviation = 0.050 Å) and the 4-methylpyrrolidine ring is 88.88 (8)°. The latter ring adopts an envelope conformation with the N atom as the flap. Its mean plane makes dihedral angles of 86.94...
Autores principales: | , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
International Union of Crystallography
2014
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3998463/ https://www.ncbi.nlm.nih.gov/pubmed/24765058 http://dx.doi.org/10.1107/S1600536814004073 |
Sumario: | In the title solvate, C(29)H(30)N(2)O(3)·CHCl(3), the dihedral angle between the indole ring system (r.m.s. deviation = 0.050 Å) and the 4-methylpyrrolidine ring is 88.88 (8)°. The latter ring adopts an envelope conformation with the N atom as the flap. Its mean plane makes dihedral angles of 86.94 (11) and 42.08 (9)° with the phenyl and dimethylbenzene rings, respectively. The molecular conformation is stabilized by intramolecular C—H⋯O hydrogen bonds, which generate S(6) and S(9) ring motifs. The chloroform solvent molecule is linked to the organic molecule by a C—H⋯O hydrogen bond involving the carbonyl O atom of the carboxylate group. In the crystal, molecules are linked via bifurcated N—H⋯(N,O) and C—H⋯O hydrogen bonds, forming chains propagating along [001]. |
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