Cargando…
5-Chloro-5′′-(4-chlorobenzylidene)-4′-(4-chlorophenyl)-1′,1′′-dimethyldispiro[indoline-3,2′-pyrrolidine-3′,3′′-piperidine]-2,4′′-dione
The racemic title compound, C(30)H(26)Cl(3)N(3)O(2), comprises two spiro links, the first connecting the piperidine and pyrrolidine rings and the other connecting the indole and pyrrolidine rings. The piperidine ring adopts a half-chair conformation, while the pyrrolidine ring has an envelope confor...
Autores principales: | , , , , |
---|---|
Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
International Union of Crystallography
2014
|
Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3998502/ https://www.ncbi.nlm.nih.gov/pubmed/24765059 http://dx.doi.org/10.1107/S1600536814004309 |
_version_ | 1782313376156745728 |
---|---|
author | Farag, I. S. Ahmed Girgis, Adel S. Ramadan, A. A. Moustafa, A. M. Mabied, Ahmed F. |
author_facet | Farag, I. S. Ahmed Girgis, Adel S. Ramadan, A. A. Moustafa, A. M. Mabied, Ahmed F. |
author_sort | Farag, I. S. Ahmed |
collection | PubMed |
description | The racemic title compound, C(30)H(26)Cl(3)N(3)O(2), comprises two spiro links, the first connecting the piperidine and pyrrolidine rings and the other connecting the indole and pyrrolidine rings. The piperidine ring adopts a half-chair conformation, while the pyrrolidine ring has an envelope conformation with the unsubstituted C atom as the flap. The dihedral angles between the two p-Cl-substituted benzene rings and the indole ring are 33.13 (14) and 54.11 (14)°. In the crystal, molecules form inversion dimers through pairs of N—H⋯O hydrogen bonds [graph set R (2) (2)(8)]. Aromatic C—H⋯O hydrogen bonds extend these dimers into a ribbon structure, enclosing R (2) (2)(14) ring motifs, along the a-axis direction. |
format | Online Article Text |
id | pubmed-3998502 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2014 |
publisher | International Union of Crystallography |
record_format | MEDLINE/PubMed |
spelling | pubmed-39985022014-04-24 5-Chloro-5′′-(4-chlorobenzylidene)-4′-(4-chlorophenyl)-1′,1′′-dimethyldispiro[indoline-3,2′-pyrrolidine-3′,3′′-piperidine]-2,4′′-dione Farag, I. S. Ahmed Girgis, Adel S. Ramadan, A. A. Moustafa, A. M. Mabied, Ahmed F. Acta Crystallogr Sect E Struct Rep Online Organic Papers The racemic title compound, C(30)H(26)Cl(3)N(3)O(2), comprises two spiro links, the first connecting the piperidine and pyrrolidine rings and the other connecting the indole and pyrrolidine rings. The piperidine ring adopts a half-chair conformation, while the pyrrolidine ring has an envelope conformation with the unsubstituted C atom as the flap. The dihedral angles between the two p-Cl-substituted benzene rings and the indole ring are 33.13 (14) and 54.11 (14)°. In the crystal, molecules form inversion dimers through pairs of N—H⋯O hydrogen bonds [graph set R (2) (2)(8)]. Aromatic C—H⋯O hydrogen bonds extend these dimers into a ribbon structure, enclosing R (2) (2)(14) ring motifs, along the a-axis direction. International Union of Crystallography 2014-02-28 /pmc/articles/PMC3998502/ /pubmed/24765059 http://dx.doi.org/10.1107/S1600536814004309 Text en © Farag et al. 2014 http://creativecommons.org/licenses/by/2.0/uk/ This is an open-access article distributed under the terms of the Creative Commons Attribution Licence, which permits unrestricted use, distribution, and reproduction in any medium, provided the original authors and source are cited. |
spellingShingle | Organic Papers Farag, I. S. Ahmed Girgis, Adel S. Ramadan, A. A. Moustafa, A. M. Mabied, Ahmed F. 5-Chloro-5′′-(4-chlorobenzylidene)-4′-(4-chlorophenyl)-1′,1′′-dimethyldispiro[indoline-3,2′-pyrrolidine-3′,3′′-piperidine]-2,4′′-dione |
title | 5-Chloro-5′′-(4-chlorobenzylidene)-4′-(4-chlorophenyl)-1′,1′′-dimethyldispiro[indoline-3,2′-pyrrolidine-3′,3′′-piperidine]-2,4′′-dione |
title_full | 5-Chloro-5′′-(4-chlorobenzylidene)-4′-(4-chlorophenyl)-1′,1′′-dimethyldispiro[indoline-3,2′-pyrrolidine-3′,3′′-piperidine]-2,4′′-dione |
title_fullStr | 5-Chloro-5′′-(4-chlorobenzylidene)-4′-(4-chlorophenyl)-1′,1′′-dimethyldispiro[indoline-3,2′-pyrrolidine-3′,3′′-piperidine]-2,4′′-dione |
title_full_unstemmed | 5-Chloro-5′′-(4-chlorobenzylidene)-4′-(4-chlorophenyl)-1′,1′′-dimethyldispiro[indoline-3,2′-pyrrolidine-3′,3′′-piperidine]-2,4′′-dione |
title_short | 5-Chloro-5′′-(4-chlorobenzylidene)-4′-(4-chlorophenyl)-1′,1′′-dimethyldispiro[indoline-3,2′-pyrrolidine-3′,3′′-piperidine]-2,4′′-dione |
title_sort | 5-chloro-5′′-(4-chlorobenzylidene)-4′-(4-chlorophenyl)-1′,1′′-dimethyldispiro[indoline-3,2′-pyrrolidine-3′,3′′-piperidine]-2,4′′-dione |
topic | Organic Papers |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3998502/ https://www.ncbi.nlm.nih.gov/pubmed/24765059 http://dx.doi.org/10.1107/S1600536814004309 |
work_keys_str_mv | AT faragisahmed 5chloro54chlorobenzylidene44chlorophenyl11dimethyldispiroindoline32pyrrolidine33piperidine24dione AT girgisadels 5chloro54chlorobenzylidene44chlorophenyl11dimethyldispiroindoline32pyrrolidine33piperidine24dione AT ramadanaa 5chloro54chlorobenzylidene44chlorophenyl11dimethyldispiroindoline32pyrrolidine33piperidine24dione AT moustafaam 5chloro54chlorobenzylidene44chlorophenyl11dimethyldispiroindoline32pyrrolidine33piperidine24dione AT mabiedahmedf 5chloro54chlorobenzylidene44chlorophenyl11dimethyldispiroindoline32pyrrolidine33piperidine24dione |