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Dectin-2 sensing of house dust mite is critical for the initiation of airway inflammation
How the immune system senses aeroallergens and triggers an aberrant inflammation is poorly understood. Dectin-2 is a house dust mite (HDM)-sensing pattern recognition receptor. In a 3-week mouse model of repeated intranasal HDM challenge, anti-Dectin-2 potently attenuated the characteristic allergic...
Autores principales: | , , , , , , , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Nature Publishing Group
2014
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3998635/ https://www.ncbi.nlm.nih.gov/pubmed/24129160 http://dx.doi.org/10.1038/mi.2013.74 |
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author | Clarke, D L Davis, N H E Campion, C L Foster, M L Heasman, S C Lewis, A R Anderson, I K Corkill, D J Sleeman, M A May, R D Robinson, M J |
author_facet | Clarke, D L Davis, N H E Campion, C L Foster, M L Heasman, S C Lewis, A R Anderson, I K Corkill, D J Sleeman, M A May, R D Robinson, M J |
author_sort | Clarke, D L |
collection | PubMed |
description | How the immune system senses aeroallergens and triggers an aberrant inflammation is poorly understood. Dectin-2 is a house dust mite (HDM)-sensing pattern recognition receptor. In a 3-week mouse model of repeated intranasal HDM challenge, anti-Dectin-2 potently attenuated the characteristic allergic inflammation and airway hyper-responsiveness. Anti-Dectin-2 also prevented neutrophil influx following a single HDM challenge. Interestingly, cysteinyl leukotrienes, but not chemokine and cytokine levels were inhibited by anti-Dectin-2 in this acute model, and in ex vivo challenge of cultured alveolar macrophages with HDM. Furthermore in the single-challenge model, zileuton, an inhibitor of leukotriene production, produced a similar effect as Dectin-2 blockade. Together these data suggest alveolar macrophage sensing of HDM by Dectin-2 elicits the production of cysteinyl leukotrienes, and this axis is key for the initiation of airway inflammation to this aeroallergen. Finally, we found Dectin-2-positive infiltrating cells present in bronchial biopsies from asthmatic subjects. |
format | Online Article Text |
id | pubmed-3998635 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2014 |
publisher | Nature Publishing Group |
record_format | MEDLINE/PubMed |
spelling | pubmed-39986352014-04-25 Dectin-2 sensing of house dust mite is critical for the initiation of airway inflammation Clarke, D L Davis, N H E Campion, C L Foster, M L Heasman, S C Lewis, A R Anderson, I K Corkill, D J Sleeman, M A May, R D Robinson, M J Mucosal Immunol Article How the immune system senses aeroallergens and triggers an aberrant inflammation is poorly understood. Dectin-2 is a house dust mite (HDM)-sensing pattern recognition receptor. In a 3-week mouse model of repeated intranasal HDM challenge, anti-Dectin-2 potently attenuated the characteristic allergic inflammation and airway hyper-responsiveness. Anti-Dectin-2 also prevented neutrophil influx following a single HDM challenge. Interestingly, cysteinyl leukotrienes, but not chemokine and cytokine levels were inhibited by anti-Dectin-2 in this acute model, and in ex vivo challenge of cultured alveolar macrophages with HDM. Furthermore in the single-challenge model, zileuton, an inhibitor of leukotriene production, produced a similar effect as Dectin-2 blockade. Together these data suggest alveolar macrophage sensing of HDM by Dectin-2 elicits the production of cysteinyl leukotrienes, and this axis is key for the initiation of airway inflammation to this aeroallergen. Finally, we found Dectin-2-positive infiltrating cells present in bronchial biopsies from asthmatic subjects. Nature Publishing Group 2014-05 2013-10-16 /pmc/articles/PMC3998635/ /pubmed/24129160 http://dx.doi.org/10.1038/mi.2013.74 Text en Copyright © 2014 Society for Mucosal Immunology http://creativecommons.org/licenses/by-nc-nd/3.0/ This work is licensed under the Creative Commons Attribution-NonCommercial-No Derivative Works 3.0 Unported License. To view a copy of this license, visit http://creativecommons.org/licenses/by-nc-nd/3.0/ |
spellingShingle | Article Clarke, D L Davis, N H E Campion, C L Foster, M L Heasman, S C Lewis, A R Anderson, I K Corkill, D J Sleeman, M A May, R D Robinson, M J Dectin-2 sensing of house dust mite is critical for the initiation of airway inflammation |
title | Dectin-2 sensing of house dust mite is critical for the initiation of airway inflammation |
title_full | Dectin-2 sensing of house dust mite is critical for the initiation of airway inflammation |
title_fullStr | Dectin-2 sensing of house dust mite is critical for the initiation of airway inflammation |
title_full_unstemmed | Dectin-2 sensing of house dust mite is critical for the initiation of airway inflammation |
title_short | Dectin-2 sensing of house dust mite is critical for the initiation of airway inflammation |
title_sort | dectin-2 sensing of house dust mite is critical for the initiation of airway inflammation |
topic | Article |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3998635/ https://www.ncbi.nlm.nih.gov/pubmed/24129160 http://dx.doi.org/10.1038/mi.2013.74 |
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