Conserved Role of Intragenic DNA Methylation in Regulating Alternative Promoters

While the methylation of DNA in 5′ promoters suppresses gene expression, the role of DNA methylation in gene bodies is unclear(1–5). In mammals, tissue- and cell type-specific methylation is present in a small percentage of 5′ CpG island (CGI) promoters, while a far greater proportion occurs across...

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Detalles Bibliográficos
Autores principales: Maunakea, Alika K., Nagarajan, Raman P., Bilenky, Mikhail, Ballinger, Tracy J., D’Souza, Cletus, Fouse, Shaun D., Johnson, Brett E., Hong, Chibo, Nielsen, Cydney, Zhao, Yongjun, Turecki, Gustavo, Delaney, Allen, Varhol, Richard, Thiessen, Nina, Shchors, Ksenya, Heine, Vivi M., Rowitch, David H., Xing, Xiaoyun, Fiore, Chris, Schillebeeckx, Maximiliaan, Jones, Steven J.M., Haussler, David, Marra, Marco A., Hirst, Martin, Wang, Ting, Costello, Joseph F.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: 2010
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3998662/
https://www.ncbi.nlm.nih.gov/pubmed/20613842
http://dx.doi.org/10.1038/nature09165

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