Is there quality control of localized mRNAs?

In eukaryotic cells many mRNAs are localized to specific regions of the cytosol, thereby allowing the local production of proteins. The process of mRNA localization can be coordinated with mRNA turnover, which can also be spatially controlled to increase the degree of mRNA localization. The coordina...

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Detalles Bibliográficos
Autores principales: Walters, Robert, Parker, Roy
Formato: Online Artículo Texto
Lenguaje:English
Publicado: The Rockefeller University Press 2014
Materias:
Reviews
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3998798/
https://www.ncbi.nlm.nih.gov/pubmed/24637320
http://dx.doi.org/10.1083/jcb.201401059
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author Walters, Robert
Parker, Roy
author_facet Walters, Robert
Parker, Roy
author_sort Walters, Robert
collection PubMed
description In eukaryotic cells many mRNAs are localized to specific regions of the cytosol, thereby allowing the local production of proteins. The process of mRNA localization can be coordinated with mRNA turnover, which can also be spatially controlled to increase the degree of mRNA localization. The coordination of mRNA localization, translation repression during transport, and mRNA degradation suggests the hypothesis that an additional layer of mRNA quality control exists in cells to degrade mRNAs that fail to be appropriately localized.
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spelling pubmed-39987982014-09-17 Is there quality control of localized mRNAs? Walters, Robert Parker, Roy J Cell Biol Reviews In eukaryotic cells many mRNAs are localized to specific regions of the cytosol, thereby allowing the local production of proteins. The process of mRNA localization can be coordinated with mRNA turnover, which can also be spatially controlled to increase the degree of mRNA localization. The coordination of mRNA localization, translation repression during transport, and mRNA degradation suggests the hypothesis that an additional layer of mRNA quality control exists in cells to degrade mRNAs that fail to be appropriately localized. The Rockefeller University Press 2014-03-17 /pmc/articles/PMC3998798/ /pubmed/24637320 http://dx.doi.org/10.1083/jcb.201401059 Text en © 2014 Walters and Parker This article is distributed under the terms of an Attribution–Noncommercial–Share Alike–No Mirror Sites license for the first six months after the publication date (see http://www.rupress.org/terms). After six months it is available under a Creative Commons License (Attribution–Noncommercial–Share Alike 3.0 Unported license, as described at http://creativecommons.org/licenses/by-nc-sa/3.0/).
spellingShingle Reviews
Walters, Robert
Parker, Roy
Is there quality control of localized mRNAs?
title Is there quality control of localized mRNAs?
title_full Is there quality control of localized mRNAs?
title_fullStr Is there quality control of localized mRNAs?
title_full_unstemmed Is there quality control of localized mRNAs?
title_short Is there quality control of localized mRNAs?
title_sort is there quality control of localized mrnas?
topic Reviews
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3998798/
https://www.ncbi.nlm.nih.gov/pubmed/24637320
http://dx.doi.org/10.1083/jcb.201401059
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