A Polymorphism in Human CD1A is Associated with Susceptibility to Tuberculosis

CD1 proteins are antigen-presenting molecules that evolved to present lipids rather than peptides to T cells. However, unlike major histocompatibility complex genes, CD1 genes show low rates of polymorphism and have not been clearly associated with human disease. We report that an intronic polymorph...

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Autores principales: Seshadri, Chetan, Thuong, Nguyen Thuy Thuong, Yen, Nguyen Thi Bich, Bang, Nguyen Duc, Chau, Tran Thi Hong, Thwaites, Guy E., Dunstan, Sarah J., Hawn, Thomas R.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: 2014
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3998877/
https://www.ncbi.nlm.nih.gov/pubmed/24500401
http://dx.doi.org/10.1038/gene.2014.5
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author Seshadri, Chetan
Thuong, Nguyen Thuy Thuong
Yen, Nguyen Thi Bich
Bang, Nguyen Duc
Chau, Tran Thi Hong
Thwaites, Guy E.
Dunstan, Sarah J.
Hawn, Thomas R.
author_facet Seshadri, Chetan
Thuong, Nguyen Thuy Thuong
Yen, Nguyen Thi Bich
Bang, Nguyen Duc
Chau, Tran Thi Hong
Thwaites, Guy E.
Dunstan, Sarah J.
Hawn, Thomas R.
author_sort Seshadri, Chetan
collection PubMed
description CD1 proteins are antigen-presenting molecules that evolved to present lipids rather than peptides to T cells. However, unlike major histocompatibility complex genes, CD1 genes show low rates of polymorphism and have not been clearly associated with human disease. We report that an intronic polymorphism in CD1A (rs411089) is associated with susceptibility to tuberculosis in two cohorts of Vietnamese adults (combined cohort odds ratio 1.78; 95%CI: 1.24-2.57; p=0.001). These data strengthen the hypothesis that CD1A-mediated lipid antigen presentation is important for controlling tuberculosis in humans.
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spelling pubmed-39988772014-10-01 A Polymorphism in Human CD1A is Associated with Susceptibility to Tuberculosis Seshadri, Chetan Thuong, Nguyen Thuy Thuong Yen, Nguyen Thi Bich Bang, Nguyen Duc Chau, Tran Thi Hong Thwaites, Guy E. Dunstan, Sarah J. Hawn, Thomas R. Genes Immun Article CD1 proteins are antigen-presenting molecules that evolved to present lipids rather than peptides to T cells. However, unlike major histocompatibility complex genes, CD1 genes show low rates of polymorphism and have not been clearly associated with human disease. We report that an intronic polymorphism in CD1A (rs411089) is associated with susceptibility to tuberculosis in two cohorts of Vietnamese adults (combined cohort odds ratio 1.78; 95%CI: 1.24-2.57; p=0.001). These data strengthen the hypothesis that CD1A-mediated lipid antigen presentation is important for controlling tuberculosis in humans. 2014-02-06 2014 /pmc/articles/PMC3998877/ /pubmed/24500401 http://dx.doi.org/10.1038/gene.2014.5 Text en Users may view, print, copy, download and text and data- mine the content in such documents, for the purposes of academic research, subject always to the full Conditions of use: http://www.nature.com/authors/editorial_policies/license.html#terms
spellingShingle Article
Seshadri, Chetan
Thuong, Nguyen Thuy Thuong
Yen, Nguyen Thi Bich
Bang, Nguyen Duc
Chau, Tran Thi Hong
Thwaites, Guy E.
Dunstan, Sarah J.
Hawn, Thomas R.
A Polymorphism in Human CD1A is Associated with Susceptibility to Tuberculosis
title A Polymorphism in Human CD1A is Associated with Susceptibility to Tuberculosis
title_full A Polymorphism in Human CD1A is Associated with Susceptibility to Tuberculosis
title_fullStr A Polymorphism in Human CD1A is Associated with Susceptibility to Tuberculosis
title_full_unstemmed A Polymorphism in Human CD1A is Associated with Susceptibility to Tuberculosis
title_short A Polymorphism in Human CD1A is Associated with Susceptibility to Tuberculosis
title_sort polymorphism in human cd1a is associated with susceptibility to tuberculosis
topic Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3998877/
https://www.ncbi.nlm.nih.gov/pubmed/24500401
http://dx.doi.org/10.1038/gene.2014.5
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