Mutations in Conserved Residues of the C. elegans microRNA Argonaute ALG-1 Identify Separable Functions in ALG-1 miRISC Loading and Target Repression

microRNAs function in diverse developmental and physiological processes by regulating target gene expression at the post-transcriptional level. ALG-1 is one of two Caenorhabditis elegans Argonautes (ALG-1 and ALG-2) that together are essential for microRNA biogenesis and function. Here, we report th...

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Detalles Bibliográficos
Autores principales: Zinovyeva, Anna Y., Bouasker, Samir, Simard, Martin J., Hammell, Christopher M., Ambros, Victor
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Public Library of Science 2014
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3998888/
https://www.ncbi.nlm.nih.gov/pubmed/24763381
http://dx.doi.org/10.1371/journal.pgen.1004286

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