Use of a Synthetic Biosensor for Neutralizing Activity-Biased Selection of Monoclonal Antibodies against Atroxlysin-I, an Hemorrhagic Metalloproteinase from Bothrops atrox Snake Venom

BACKGROUND: The snake Bothrops atrox is responsible for the majority of envenomings in the northern region of South America. Severe local effects, including hemorrhage, which are mainly caused by snake venom metalloproteinases (SVMPs), are not fully neutralized by conventional serum therapy. Little...

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Detalles Bibliográficos
Autores principales: Schneider, Francisco Santos, Nguyen, Dung Le, Castro, Karen Larissa, Cobo, Sandra, Machado de Avila, Ricardo Andrez, Ferreira, Nivia de Assis, Sanchez, Eladio Flores, Nguyen, Christophe, Granier, Claude, Galéa, Pascale, Chávez-Olortegui, Carlos, Molina, Franck
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Public Library of Science 2014
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3998924/
https://www.ncbi.nlm.nih.gov/pubmed/24762927
http://dx.doi.org/10.1371/journal.pntd.0002826

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