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Longer Telomere Length in COPD Patients with α(1)-Antitrypsin Deficiency Independent of Lung Function
Oxidative stress is involved in the pathogenesis of airway obstruction in α(1)-antitrypsin deficient patients. This may result in a shortening of telomere length, resulting in cellular senescence. To test whether telomere length differs in α(1)-antitrypsin deficient patients compared with controls,...
Autores principales: | , , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Public Library of Science
2014
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3998943/ https://www.ncbi.nlm.nih.gov/pubmed/24763308 http://dx.doi.org/10.1371/journal.pone.0095600 |
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author | Saferali, Aabida Lee, Jee Sin, Don D. Rouhani, Farshid N. Brantly, Mark L. Sandford, Andrew J. |
author_facet | Saferali, Aabida Lee, Jee Sin, Don D. Rouhani, Farshid N. Brantly, Mark L. Sandford, Andrew J. |
author_sort | Saferali, Aabida |
collection | PubMed |
description | Oxidative stress is involved in the pathogenesis of airway obstruction in α(1)-antitrypsin deficient patients. This may result in a shortening of telomere length, resulting in cellular senescence. To test whether telomere length differs in α(1)-antitrypsin deficient patients compared with controls, we measured telomere length in DNA from peripheral blood cells of 217 α(1)-antitrypsin deficient patients and 217 control COPD patients. We also tested for differences in telomere length between DNA from blood and DNA from lung tissue in a subset of 51 controls. We found that telomere length in the blood was significantly longer in α(1)-antitrypsin deficient COPD patients compared with control COPD patients (p = 1×10(−29)). Telomere length was not related to lung function in α(1)-antitrypsin deficient patients (p = 0.3122) or in COPD controls (p = 0.1430). Although mean telomere length was significantly shorter in the blood when compared with the lungs (p = 0.0078), telomere length was correlated between the two tissue types (p = 0.0122). Our results indicate that telomere length is better preserved in α(1)-antitrypsin deficient COPD patients than in non-deficient patients. In addition, measurement of telomere length in the blood may be a suitable surrogate for measurement in the lung. |
format | Online Article Text |
id | pubmed-3998943 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2014 |
publisher | Public Library of Science |
record_format | MEDLINE/PubMed |
spelling | pubmed-39989432014-04-29 Longer Telomere Length in COPD Patients with α(1)-Antitrypsin Deficiency Independent of Lung Function Saferali, Aabida Lee, Jee Sin, Don D. Rouhani, Farshid N. Brantly, Mark L. Sandford, Andrew J. PLoS One Research Article Oxidative stress is involved in the pathogenesis of airway obstruction in α(1)-antitrypsin deficient patients. This may result in a shortening of telomere length, resulting in cellular senescence. To test whether telomere length differs in α(1)-antitrypsin deficient patients compared with controls, we measured telomere length in DNA from peripheral blood cells of 217 α(1)-antitrypsin deficient patients and 217 control COPD patients. We also tested for differences in telomere length between DNA from blood and DNA from lung tissue in a subset of 51 controls. We found that telomere length in the blood was significantly longer in α(1)-antitrypsin deficient COPD patients compared with control COPD patients (p = 1×10(−29)). Telomere length was not related to lung function in α(1)-antitrypsin deficient patients (p = 0.3122) or in COPD controls (p = 0.1430). Although mean telomere length was significantly shorter in the blood when compared with the lungs (p = 0.0078), telomere length was correlated between the two tissue types (p = 0.0122). Our results indicate that telomere length is better preserved in α(1)-antitrypsin deficient COPD patients than in non-deficient patients. In addition, measurement of telomere length in the blood may be a suitable surrogate for measurement in the lung. Public Library of Science 2014-04-24 /pmc/articles/PMC3998943/ /pubmed/24763308 http://dx.doi.org/10.1371/journal.pone.0095600 Text en © 2014 Saferali et al http://creativecommons.org/licenses/by/4.0/ This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are properly credited. |
spellingShingle | Research Article Saferali, Aabida Lee, Jee Sin, Don D. Rouhani, Farshid N. Brantly, Mark L. Sandford, Andrew J. Longer Telomere Length in COPD Patients with α(1)-Antitrypsin Deficiency Independent of Lung Function |
title | Longer Telomere Length in COPD Patients with α(1)-Antitrypsin Deficiency Independent of Lung Function |
title_full | Longer Telomere Length in COPD Patients with α(1)-Antitrypsin Deficiency Independent of Lung Function |
title_fullStr | Longer Telomere Length in COPD Patients with α(1)-Antitrypsin Deficiency Independent of Lung Function |
title_full_unstemmed | Longer Telomere Length in COPD Patients with α(1)-Antitrypsin Deficiency Independent of Lung Function |
title_short | Longer Telomere Length in COPD Patients with α(1)-Antitrypsin Deficiency Independent of Lung Function |
title_sort | longer telomere length in copd patients with α(1)-antitrypsin deficiency independent of lung function |
topic | Research Article |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3998943/ https://www.ncbi.nlm.nih.gov/pubmed/24763308 http://dx.doi.org/10.1371/journal.pone.0095600 |
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