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Dimerization Interface of 3-Hydroxyacyl-CoA Dehydrogenase Tunes the Formation of Its Catalytic Intermediate

3-hydroxyacyl-CoA dehydrogenase (HAD, EC 1.1.1.35) is a homodimeric enzyme localized in the mitochondrial matrix, which catalyzes the third step in fatty acid β-oxidation. The crystal structures of human HAD and subsequent complexes with cofactor/substrate enabled better understanding of HAD catalyt...

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Detalles Bibliográficos
Autores principales:	Xu, Yingzhi, Li, He, Jin, Ying-Hua, Fan, Jun, Sun, Fei
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Public Library of Science 2014
Materias:	Research Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3999109/ https://www.ncbi.nlm.nih.gov/pubmed/24763278 http://dx.doi.org/10.1371/journal.pone.0095965

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