Fusion to the Lysosome Targeting Signal of the Invariant Chain Alters the Processing and Enhances the Immunogenicity of HIV-1 Reverse Transcriptase

Intracellular processing of the antigen encoded by a DNA vaccine is one of the key steps in generating an immune response. Immunization with DNA constructs targeted to the endosomal-lysosomal compartments and to the MHC class II pathway can elicit a strong immune response. Herein, the weakly immunog...

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Detalles Bibliográficos
Autores principales: Starodubova, E. S., Isaguliants, M. G., Kuzmenko, Y. V., Latanova, A. A., Krotova, O. A., Karpov, V. L.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: A.I. Gordeyev 2014
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3999467/
https://www.ncbi.nlm.nih.gov/pubmed/24772328

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