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Assessment of endothelium: Dependent vasodilation with a non-invasive method in patients with preeclampsia compared to normotensive pregnant women

BACKGROUND: To assess the endothelial function via noninvasive method, in pregnant women with preeclampsia compared to to normotensive pregnant women. MATERIALS AND METHODS: Brachial artery diameter was measured via ultrasound, in 28 women with preeclampcia in case group and normotensive pregnant wo...

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Autores principales: Allameh, Seyedeh Zahra, Tehrani, Hatav Ghasemi, Hashemi, Seyyed Mohammad, Nia, Reza Basirat, Hoseini, Forough
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Medknow Publications & Media Pvt Ltd 2014
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Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3999604/
https://www.ncbi.nlm.nih.gov/pubmed/24778672
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author Allameh, Seyedeh Zahra
Tehrani, Hatav Ghasemi
Hashemi, Seyyed Mohammad
Nia, Reza Basirat
Hoseini, Forough
author_facet Allameh, Seyedeh Zahra
Tehrani, Hatav Ghasemi
Hashemi, Seyyed Mohammad
Nia, Reza Basirat
Hoseini, Forough
author_sort Allameh, Seyedeh Zahra
collection PubMed
description BACKGROUND: To assess the endothelial function via noninvasive method, in pregnant women with preeclampsia compared to to normotensive pregnant women. MATERIALS AND METHODS: Brachial artery diameter was measured via ultrasound, in 28 women with preeclampcia in case group and normotensive pregnant women in control group, at rest, after inflation of sphygmomanometer cuff up to 250-300 mmHg, immediately after deflation of the cuff, 60-90 minutes later and 5 min after administration of sublingual trinitroglycerin (TNG). Results of these measurements as well as demographic characteristics of participants in both groups were recorded in special forms. Data were analyzed via Statistical Package for Social Sciences (SPSS) version 16, using t-test and repeated measures analysis of variance (ANOVA). P-value < 0.05 was considered statistically significant. The results were presented as mean ± standard deviation (SD). RESULTS: The mean of brachial artery diameter at rest in the case and control groups was 4.49 ± 0.39 and 4.08 ± 0.38 mm, respectively (P = 0.1). Also the results showed that the brachial artery diameter, immediately after deflation of the cuff, was 4.84 ± 0.4 and 4.37 ± 0.30 mm in the case and control groups (P < 0.001), respectively. The mean brachial artery diameter, 60-90 s after deflation of the cuff, was 4.82 ± 0.41 and 4.42 ± 0.38 mm in the case and control groups (P < 0.00), respectively. The brachial artery diameter, 5 min after sublingual NO administration, was 4.95 ± 0.6 and 4.40 ± 0.45 mm in case and control groups (P < 0.001), respectively. Applying of repeated measures ANOVA showed that the mean difference between case and control groups was statistically significant (P < 0.001). CONCLUSION: Current study concluded that there is no difference in endothelium-dependent vasodilation between women with preeclampsia and pregnant women with normal blood pressure.
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spelling pubmed-39996042014-04-28 Assessment of endothelium: Dependent vasodilation with a non-invasive method in patients with preeclampsia compared to normotensive pregnant women Allameh, Seyedeh Zahra Tehrani, Hatav Ghasemi Hashemi, Seyyed Mohammad Nia, Reza Basirat Hoseini, Forough J Res Med Sci Short Communication BACKGROUND: To assess the endothelial function via noninvasive method, in pregnant women with preeclampsia compared to to normotensive pregnant women. MATERIALS AND METHODS: Brachial artery diameter was measured via ultrasound, in 28 women with preeclampcia in case group and normotensive pregnant women in control group, at rest, after inflation of sphygmomanometer cuff up to 250-300 mmHg, immediately after deflation of the cuff, 60-90 minutes later and 5 min after administration of sublingual trinitroglycerin (TNG). Results of these measurements as well as demographic characteristics of participants in both groups were recorded in special forms. Data were analyzed via Statistical Package for Social Sciences (SPSS) version 16, using t-test and repeated measures analysis of variance (ANOVA). P-value < 0.05 was considered statistically significant. The results were presented as mean ± standard deviation (SD). RESULTS: The mean of brachial artery diameter at rest in the case and control groups was 4.49 ± 0.39 and 4.08 ± 0.38 mm, respectively (P = 0.1). Also the results showed that the brachial artery diameter, immediately after deflation of the cuff, was 4.84 ± 0.4 and 4.37 ± 0.30 mm in the case and control groups (P < 0.001), respectively. The mean brachial artery diameter, 60-90 s after deflation of the cuff, was 4.82 ± 0.41 and 4.42 ± 0.38 mm in the case and control groups (P < 0.00), respectively. The brachial artery diameter, 5 min after sublingual NO administration, was 4.95 ± 0.6 and 4.40 ± 0.45 mm in case and control groups (P < 0.001), respectively. Applying of repeated measures ANOVA showed that the mean difference between case and control groups was statistically significant (P < 0.001). CONCLUSION: Current study concluded that there is no difference in endothelium-dependent vasodilation between women with preeclampsia and pregnant women with normal blood pressure. Medknow Publications & Media Pvt Ltd 2014-02 /pmc/articles/PMC3999604/ /pubmed/24778672 Text en Copyright: © Journal of Research in Medical Sciences http://creativecommons.org/licenses/by-nc-sa/3.0 This is an open-access article distributed under the terms of the Creative Commons Attribution-Noncommercial-Share Alike 3.0 Unported, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.
spellingShingle Short Communication
Allameh, Seyedeh Zahra
Tehrani, Hatav Ghasemi
Hashemi, Seyyed Mohammad
Nia, Reza Basirat
Hoseini, Forough
Assessment of endothelium: Dependent vasodilation with a non-invasive method in patients with preeclampsia compared to normotensive pregnant women
title Assessment of endothelium: Dependent vasodilation with a non-invasive method in patients with preeclampsia compared to normotensive pregnant women
title_full Assessment of endothelium: Dependent vasodilation with a non-invasive method in patients with preeclampsia compared to normotensive pregnant women
title_fullStr Assessment of endothelium: Dependent vasodilation with a non-invasive method in patients with preeclampsia compared to normotensive pregnant women
title_full_unstemmed Assessment of endothelium: Dependent vasodilation with a non-invasive method in patients with preeclampsia compared to normotensive pregnant women
title_short Assessment of endothelium: Dependent vasodilation with a non-invasive method in patients with preeclampsia compared to normotensive pregnant women
title_sort assessment of endothelium: dependent vasodilation with a non-invasive method in patients with preeclampsia compared to normotensive pregnant women
topic Short Communication
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3999604/
https://www.ncbi.nlm.nih.gov/pubmed/24778672
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