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Frontal Fibrosing Alopecia and Lupus Overlap in a Man: Guilt by Association?
Frontal fibrosing alopecia (FFA) is a scarring alopecia, now an accepted subset variant of lichen planopilaris (LPP). Its occurrence in males is rare, with only nine cases reported to date. We describe a case of FFA in a male in association with lupus erythematosus. Multiple biopsies from the scalp,...
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Formato: | Online Artículo Texto |
Lenguaje: | English |
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Medknow Publications & Media Pvt Ltd
2013
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Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3999657/ https://www.ncbi.nlm.nih.gov/pubmed/24778537 http://dx.doi.org/10.4103/0974-7753.130420 |
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author | Khan, Sabrina Fenton, David A Stefanato, Catherine M |
author_facet | Khan, Sabrina Fenton, David A Stefanato, Catherine M |
author_sort | Khan, Sabrina |
collection | PubMed |
description | Frontal fibrosing alopecia (FFA) is a scarring alopecia, now an accepted subset variant of lichen planopilaris (LPP). Its occurrence in males is rare, with only nine cases reported to date. We describe a case of FFA in a male in association with lupus erythematosus. Multiple biopsies from the scalp, eyebrow and arm showed features consistent with LPP, in keeping with the clinical presentation of FFA. Direct immunofluorescence studies showed a positive lupus band test. Further serological investigation confirmed the presence of antinuclear, anticardiolipin and lupus anticoagulant antibodies. Whilst the findings of lupus erythematosus may be coincidental or a forme fruste of the disease occurring in association with FFA, it is feasible that lupus and LPP may occur as an overlap syndrome. This case underscores the importance of multiple biopsies and the role of direct immunofluorescence in disclosing more than one pathology in the follow-up of patients with scarring alopecia. |
format | Online Article Text |
id | pubmed-3999657 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2013 |
publisher | Medknow Publications & Media Pvt Ltd |
record_format | MEDLINE/PubMed |
spelling | pubmed-39996572014-04-28 Frontal Fibrosing Alopecia and Lupus Overlap in a Man: Guilt by Association? Khan, Sabrina Fenton, David A Stefanato, Catherine M Int J Trichology Case Report Frontal fibrosing alopecia (FFA) is a scarring alopecia, now an accepted subset variant of lichen planopilaris (LPP). Its occurrence in males is rare, with only nine cases reported to date. We describe a case of FFA in a male in association with lupus erythematosus. Multiple biopsies from the scalp, eyebrow and arm showed features consistent with LPP, in keeping with the clinical presentation of FFA. Direct immunofluorescence studies showed a positive lupus band test. Further serological investigation confirmed the presence of antinuclear, anticardiolipin and lupus anticoagulant antibodies. Whilst the findings of lupus erythematosus may be coincidental or a forme fruste of the disease occurring in association with FFA, it is feasible that lupus and LPP may occur as an overlap syndrome. This case underscores the importance of multiple biopsies and the role of direct immunofluorescence in disclosing more than one pathology in the follow-up of patients with scarring alopecia. Medknow Publications & Media Pvt Ltd 2013 /pmc/articles/PMC3999657/ /pubmed/24778537 http://dx.doi.org/10.4103/0974-7753.130420 Text en Copyright: © International Journal of Trichology http://creativecommons.org/licenses/by-nc-sa/3.0 This is an open-access article distributed under the terms of the Creative Commons Attribution-Noncommercial-Share Alike 3.0 Unported, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited. |
spellingShingle | Case Report Khan, Sabrina Fenton, David A Stefanato, Catherine M Frontal Fibrosing Alopecia and Lupus Overlap in a Man: Guilt by Association? |
title | Frontal Fibrosing Alopecia and Lupus Overlap in a Man: Guilt by Association? |
title_full | Frontal Fibrosing Alopecia and Lupus Overlap in a Man: Guilt by Association? |
title_fullStr | Frontal Fibrosing Alopecia and Lupus Overlap in a Man: Guilt by Association? |
title_full_unstemmed | Frontal Fibrosing Alopecia and Lupus Overlap in a Man: Guilt by Association? |
title_short | Frontal Fibrosing Alopecia and Lupus Overlap in a Man: Guilt by Association? |
title_sort | frontal fibrosing alopecia and lupus overlap in a man: guilt by association? |
topic | Case Report |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3999657/ https://www.ncbi.nlm.nih.gov/pubmed/24778537 http://dx.doi.org/10.4103/0974-7753.130420 |
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