Cargando…

Diagnostic utility of adenosine deaminase in exudative pleural effusions

OBJECTIVE: To determine the diagnostic utility of adenosine deaminase (ADA) in exudative pleural effusions of different etiologies. SETTING AND DESIGN: It was an observational study conducted at a tertiary care teaching institute. MATERIALS AND METHODS: Of a total of 171 pleural fluid samples, 122 w...

Descripción completa

Detalles Bibliográficos
Autores principales: Mehta, Asmita A., Gupta, Amit Satish, Ahmed, Subin, Rajesh, V.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Medknow Publications & Media Pvt Ltd 2014
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3999674/
https://www.ncbi.nlm.nih.gov/pubmed/24778477
http://dx.doi.org/10.4103/0970-2113.129842
_version_ 1782313520843456512
author Mehta, Asmita A.
Gupta, Amit Satish
Ahmed, Subin
Rajesh, V.
author_facet Mehta, Asmita A.
Gupta, Amit Satish
Ahmed, Subin
Rajesh, V.
author_sort Mehta, Asmita A.
collection PubMed
description OBJECTIVE: To determine the diagnostic utility of adenosine deaminase (ADA) in exudative pleural effusions of different etiologies. SETTING AND DESIGN: It was an observational study conducted at a tertiary care teaching institute. MATERIALS AND METHODS: Of a total of 171 pleural fluid samples, 122 were found to be exudates and were included in the study. Pleural fluid ADA was done for all included patients. Pleural fluid ADA ≥40 U/l was taken as diagnostic cut off for TB effusion. STATISTICAL ANALYSIS: Sensitivity, specificity positive and negative predictive value of pleural fluid ADA for diagnosing TB was calculated by using clinical calculator – 1, Richard Lowry 2001-2013. RESULTS: There were 171 patients with pleural effusion, out of which 122 (71.8%) were found to be exudative and were studied further. There were 49 (40.1%), 36 (29.5%) and 33 (27%) cases of TB, malignancy and para pneumonic effusion respectively, whereas 4 (3.3%) cases remained undiagnosed. Median ADA values for TB, malignancy and para pneumonic effusion were 55.8 U/l (range 9.7-756 U/l), 18 U/l (6.5-81 U/l) and 25 U/l (3.4-172 U/l) respectively. Pleural fluid ADA >40U/l yielded 85.7% sensitivity, 80.8% specificity, 75% positive predictive value and 89.5% negative predictive value. CONCLUSION: Pleural fluid ADA remains useful in diagnosing tuberculosis pleural effusion. The median ADA for TB effusion in present cohort was 51.8 IU/ml. Pleural fluid ADA of 40 U/L yielded 89.5% negative predictive value and 75% positive predictive value. Pleural fluid ADA is cost effective and good screening test for diagnosis of TB.
format Online
Article
Text
id pubmed-3999674
institution National Center for Biotechnology Information
language English
publishDate 2014
publisher Medknow Publications & Media Pvt Ltd
record_format MEDLINE/PubMed
spelling pubmed-39996742014-04-28 Diagnostic utility of adenosine deaminase in exudative pleural effusions Mehta, Asmita A. Gupta, Amit Satish Ahmed, Subin Rajesh, V. Lung India Original Article OBJECTIVE: To determine the diagnostic utility of adenosine deaminase (ADA) in exudative pleural effusions of different etiologies. SETTING AND DESIGN: It was an observational study conducted at a tertiary care teaching institute. MATERIALS AND METHODS: Of a total of 171 pleural fluid samples, 122 were found to be exudates and were included in the study. Pleural fluid ADA was done for all included patients. Pleural fluid ADA ≥40 U/l was taken as diagnostic cut off for TB effusion. STATISTICAL ANALYSIS: Sensitivity, specificity positive and negative predictive value of pleural fluid ADA for diagnosing TB was calculated by using clinical calculator – 1, Richard Lowry 2001-2013. RESULTS: There were 171 patients with pleural effusion, out of which 122 (71.8%) were found to be exudative and were studied further. There were 49 (40.1%), 36 (29.5%) and 33 (27%) cases of TB, malignancy and para pneumonic effusion respectively, whereas 4 (3.3%) cases remained undiagnosed. Median ADA values for TB, malignancy and para pneumonic effusion were 55.8 U/l (range 9.7-756 U/l), 18 U/l (6.5-81 U/l) and 25 U/l (3.4-172 U/l) respectively. Pleural fluid ADA >40U/l yielded 85.7% sensitivity, 80.8% specificity, 75% positive predictive value and 89.5% negative predictive value. CONCLUSION: Pleural fluid ADA remains useful in diagnosing tuberculosis pleural effusion. The median ADA for TB effusion in present cohort was 51.8 IU/ml. Pleural fluid ADA of 40 U/L yielded 89.5% negative predictive value and 75% positive predictive value. Pleural fluid ADA is cost effective and good screening test for diagnosis of TB. Medknow Publications & Media Pvt Ltd 2014 /pmc/articles/PMC3999674/ /pubmed/24778477 http://dx.doi.org/10.4103/0970-2113.129842 Text en Copyright: © Lung India http://creativecommons.org/licenses/by-nc-sa/3.0 This is an open-access article distributed under the terms of the Creative Commons Attribution-Noncommercial-Share Alike 3.0 Unported, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.
spellingShingle Original Article
Mehta, Asmita A.
Gupta, Amit Satish
Ahmed, Subin
Rajesh, V.
Diagnostic utility of adenosine deaminase in exudative pleural effusions
title Diagnostic utility of adenosine deaminase in exudative pleural effusions
title_full Diagnostic utility of adenosine deaminase in exudative pleural effusions
title_fullStr Diagnostic utility of adenosine deaminase in exudative pleural effusions
title_full_unstemmed Diagnostic utility of adenosine deaminase in exudative pleural effusions
title_short Diagnostic utility of adenosine deaminase in exudative pleural effusions
title_sort diagnostic utility of adenosine deaminase in exudative pleural effusions
topic Original Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3999674/
https://www.ncbi.nlm.nih.gov/pubmed/24778477
http://dx.doi.org/10.4103/0970-2113.129842
work_keys_str_mv AT mehtaasmitaa diagnosticutilityofadenosinedeaminaseinexudativepleuraleffusions
AT guptaamitsatish diagnosticutilityofadenosinedeaminaseinexudativepleuraleffusions
AT ahmedsubin diagnosticutilityofadenosinedeaminaseinexudativepleuraleffusions
AT rajeshv diagnosticutilityofadenosinedeaminaseinexudativepleuraleffusions