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Identification of Thyroid Hormone Receptor Active Compounds Using a Quantitative High-Throughput Screening Platform

To adapt the use of GH3.TRE-Luc reporter gene cell line for a quantitative high-throughput screening (qHTS) platform, we miniaturized the reporter gene assay to a 1536-well plate format. 1280 chemicals from the Library of Pharmacologically Active Compounds (LOPAC) and the National Toxicology Program...

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Detalles Bibliográficos
Autores principales:	Freitas, Jaime, Miller, Nicole, Mengeling, Brenda J., Xia, Menghang, Huang, Ruili, Houck, Keith, Rietjens, Ivonne M.C.M., Furlow, J. David, Murk, Albertinka J.
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Bentham Open 2014
Materias:	Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3999704/ https://www.ncbi.nlm.nih.gov/pubmed/24772387 http://dx.doi.org/10.2174/2213988501408010036

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