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Repair of naturally occurring mismatches can induce mutations in flanking DNA

‘Normal’ genomic DNA contains hundreds of mismatches that are generated daily by the spontaneous deamination of C (U/G) and methyl-C (T/G). Thus, a mutagenic effect of their repair could constitute a serious genetic burden. We show here that while mismatches introduced into human cells on an SV40-ba...

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Detalles Bibliográficos
Autores principales:	Chen, Jia, Miller, Brendan F, Furano, Anthony V
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	eLife Sciences Publications, Ltd 2014
Materias:	Biochemistry
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3999860/ https://www.ncbi.nlm.nih.gov/pubmed/24843013 http://dx.doi.org/10.7554/eLife.02001

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