MicroRNA-566 activates EGFR signaling and its inhibition sensitizes glioblastoma cells to nimotuzumab

BACKGROUND: Epidermal growth factor receptor (EGFR) is amplified in 40% of human glioblastomas. However, most glioblastoma patients respond poorly to anti-EGFR therapy. MicroRNAs can function as either oncogenes or tumor suppressor genes, and have been shown to play an important role in cancer cell...

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Detalles Bibliográficos
Autores principales: Zhang, Kai-Liang, Zhou, Xuan, Han, Lei, Chen, Lu-Yue, Chen, Ling-Chao, Shi, Zhen-Dong, Yang, Ming, Ren, Yu, Yang, Jing-Xuan, Frank, Thomas S, Zhang, Chuan-Bao, Zhang, Jun-Xia, Pu, Pei-Yu, Zhang, Jian-Ning, Jiang, Tao, Wagner, Eric J, Li, Min, Kang, Chun-Sheng
Formato: Online Artículo Texto
Lenguaje:English
Publicado: BioMed Central 2014
Materias:
Research
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3999939/
https://www.ncbi.nlm.nih.gov/pubmed/24650032
http://dx.doi.org/10.1186/1476-4598-13-63

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