Pathology and Neurotoxicity in Dogs after Repeat Dose Exposure to a Serotonin 5-HT(1B) Inhibitor

AZD3783, a cationic amphiphilic drug and a potent inhibitor of the 5-hydroxytryptamine (5-HT(1B)) receptor, was explored as a potential treatment for depression. To support clinical trials, repeat dose toxicity studies in rats and dogs were conducted. Here we report toxicity findings in dogs after d...

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Detalles Bibliográficos
Autores principales: Chang, Jane C.F., Ciaccio, Paul, Schroeder, Patricia, Wright, Lindsay, Westwood, Russell, Berg, Anna-Lena
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Japanese Society of Toxicologic Pathology 2014
Materias:
Original Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4000071/
https://www.ncbi.nlm.nih.gov/pubmed/24791065
http://dx.doi.org/10.1293/tox.2013-0033

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4000071/
https://www.ncbi.nlm.nih.gov/pubmed/24791065
http://dx.doi.org/10.1293/tox.2013-0033

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